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Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database

BACKGROUND: Cyclin F (CCNF) dysfunction has been implicated in various forms of cancer, offering a new avenue for understanding the pathogenic mechanisms underlying hepatocellular carcinoma (HCC). We aimed to evaluate the role of CCNF in HCC using publicly available data from The Cancer Genome Atlas...

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Autores principales: Zelong, Yang, Han, Yang, Ting, Guo, Yifei, Wang, Kun, He, Haoran, Hu, Yong, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341327/
https://www.ncbi.nlm.nih.gov/pubmed/34397798
http://dx.doi.org/10.1097/MD.0000000000026623
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author Zelong, Yang
Han, Yang
Ting, Guo
Yifei, Wang
Kun, He
Haoran, Hu
Yong, Chen
author_facet Zelong, Yang
Han, Yang
Ting, Guo
Yifei, Wang
Kun, He
Haoran, Hu
Yong, Chen
author_sort Zelong, Yang
collection PubMed
description BACKGROUND: Cyclin F (CCNF) dysfunction has been implicated in various forms of cancer, offering a new avenue for understanding the pathogenic mechanisms underlying hepatocellular carcinoma (HCC). We aimed to evaluate the role of CCNF in HCC using publicly available data from The Cancer Genome Atlas (TCGA). METHOD: We used TCGA data and Gene Expression Omnibus (GEO) data to analyze the differential expression of CCNF between tumor and adjacent tissues and the relationship between CCNF and clinical characteristics. We compared prognosis of patients with HCC with high and low CCNF expression and constructed receiver operating characteristic (ROC) curves. In addition, we also explored the types of gene mutations in relevant groups and conducted Gene Set Enrichment Analysis (GSEA). RESULTS: The expression of CCNF in liver cancer tissues was significantly increased compared with that in adjacent tissues, and patients with high CCNF expression had a worse prognosis than those with low CCNF expression. Patients with high CCNF expression also had more somatic mutations. High expression of CCNF hampers the prognosis independently. The GSEA showed that the "http://www.gsea-msigdb.org/gsea/msigdb/cards/BIOCARTA_WNT_PATHWAY" Wnt pathway, "http://www.gsea-msigdb.org/gsea/msigdb/cards/BIOCARTA_P53_PATHWAY" P53 pathway, "http://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING" PI3K/Akt/mTOR pathway, "http://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_NOTCH_SIGNALING" Notch pathway were enriched in patients with the high CCNF expression phenotype. CONCLUSION: High CCNF expression can be seen as an independent risk factor for poor survival in HCC. Its expression may serve as a target for the diagnosis and treatment of liver cancer.
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spelling pubmed-83413272021-08-07 Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database Zelong, Yang Han, Yang Ting, Guo Yifei, Wang Kun, He Haoran, Hu Yong, Chen Medicine (Baltimore) 5700 BACKGROUND: Cyclin F (CCNF) dysfunction has been implicated in various forms of cancer, offering a new avenue for understanding the pathogenic mechanisms underlying hepatocellular carcinoma (HCC). We aimed to evaluate the role of CCNF in HCC using publicly available data from The Cancer Genome Atlas (TCGA). METHOD: We used TCGA data and Gene Expression Omnibus (GEO) data to analyze the differential expression of CCNF between tumor and adjacent tissues and the relationship between CCNF and clinical characteristics. We compared prognosis of patients with HCC with high and low CCNF expression and constructed receiver operating characteristic (ROC) curves. In addition, we also explored the types of gene mutations in relevant groups and conducted Gene Set Enrichment Analysis (GSEA). RESULTS: The expression of CCNF in liver cancer tissues was significantly increased compared with that in adjacent tissues, and patients with high CCNF expression had a worse prognosis than those with low CCNF expression. Patients with high CCNF expression also had more somatic mutations. High expression of CCNF hampers the prognosis independently. The GSEA showed that the "http://www.gsea-msigdb.org/gsea/msigdb/cards/BIOCARTA_WNT_PATHWAY" Wnt pathway, "http://www.gsea-msigdb.org/gsea/msigdb/cards/BIOCARTA_P53_PATHWAY" P53 pathway, "http://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING" PI3K/Akt/mTOR pathway, "http://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_NOTCH_SIGNALING" Notch pathway were enriched in patients with the high CCNF expression phenotype. CONCLUSION: High CCNF expression can be seen as an independent risk factor for poor survival in HCC. Its expression may serve as a target for the diagnosis and treatment of liver cancer. Lippincott Williams & Wilkins 2021-08-06 /pmc/articles/PMC8341327/ /pubmed/34397798 http://dx.doi.org/10.1097/MD.0000000000026623 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 5700
Zelong, Yang
Han, Yang
Ting, Guo
Yifei, Wang
Kun, He
Haoran, Hu
Yong, Chen
Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database
title Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database
title_full Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database
title_fullStr Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database
title_full_unstemmed Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database
title_short Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database
title_sort increased expression of cyclin f in liver cancer predicts poor prognosis: a study based on tcga database
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341327/
https://www.ncbi.nlm.nih.gov/pubmed/34397798
http://dx.doi.org/10.1097/MD.0000000000026623
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