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Clinical therapeutic effects of opioid analgesia for acute abdominal pain in children and young adults: A protocol for systematic review and meta-analysis

BACKGROUND: Nearly 10% of all patients who visit the emergency department report severe abdominal pain. Out of these, almost one-third are not diagnosed accurately. The conventional practice to care for such inpatients involves actively managed observation and repetitive clinical assessments at regu...

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Autores principales: Li, Jie, Hu, Fei-Yan, Zhong, Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341341/
https://www.ncbi.nlm.nih.gov/pubmed/34397791
http://dx.doi.org/10.1097/MD.0000000000026402
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author Li, Jie
Hu, Fei-Yan
Zhong, Guo
author_facet Li, Jie
Hu, Fei-Yan
Zhong, Guo
author_sort Li, Jie
collection PubMed
description BACKGROUND: Nearly 10% of all patients who visit the emergency department report severe abdominal pain. Out of these, almost one-third are not diagnosed accurately. The conventional practice to care for such inpatients involves actively managed observation and repetitive clinical assessments at regular intervals. The aim of this study is to assess the clinical therapeutic effects of opioid analgesia in the treatment of severe abdominal pain in kids and adolescents. METHODS: A comprehensive electronic search will be done on Web of Science, EMBASE, PubMed, WanFang database, Chinese National Knowledge Infrastructure, and the Cochrane Library from their establishment to May 2021. The search will identify and retrieve all randomized controlled trials that describe the clinical therapeutic effects of opioid analgesia to treat severe abdominal pain in adolescents and children. Two independent authors will shortlist studies that meet the inclusion criteria, extract data from selected studies, and evaluate the risk associated with bias in the selected articles. We will use RevMan (v: 5.3) to conduct all the data synthesis. RESULTS: This meta-analysis will conduct a high-quality synthesis on present evidence related to the usage of opioid analgesia to treat severe abdominal pain in both kids and adolescents. CONCLUSION: Our findings will summarize the present evidence and help judge whether opioid analgesia is an effective and safe line of treatment for severe abdominal pain. ETHICS AND DISSEMINATION: This study will use pre-published data, and as such, it does not require ethics approval. OSF REGISTRATION NUMBER: May 29, 2021.osf.io/fp9ym (https://osf.io/fp9ym/).
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spelling pubmed-83413412021-08-07 Clinical therapeutic effects of opioid analgesia for acute abdominal pain in children and young adults: A protocol for systematic review and meta-analysis Li, Jie Hu, Fei-Yan Zhong, Guo Medicine (Baltimore) 3900 BACKGROUND: Nearly 10% of all patients who visit the emergency department report severe abdominal pain. Out of these, almost one-third are not diagnosed accurately. The conventional practice to care for such inpatients involves actively managed observation and repetitive clinical assessments at regular intervals. The aim of this study is to assess the clinical therapeutic effects of opioid analgesia in the treatment of severe abdominal pain in kids and adolescents. METHODS: A comprehensive electronic search will be done on Web of Science, EMBASE, PubMed, WanFang database, Chinese National Knowledge Infrastructure, and the Cochrane Library from their establishment to May 2021. The search will identify and retrieve all randomized controlled trials that describe the clinical therapeutic effects of opioid analgesia to treat severe abdominal pain in adolescents and children. Two independent authors will shortlist studies that meet the inclusion criteria, extract data from selected studies, and evaluate the risk associated with bias in the selected articles. We will use RevMan (v: 5.3) to conduct all the data synthesis. RESULTS: This meta-analysis will conduct a high-quality synthesis on present evidence related to the usage of opioid analgesia to treat severe abdominal pain in both kids and adolescents. CONCLUSION: Our findings will summarize the present evidence and help judge whether opioid analgesia is an effective and safe line of treatment for severe abdominal pain. ETHICS AND DISSEMINATION: This study will use pre-published data, and as such, it does not require ethics approval. OSF REGISTRATION NUMBER: May 29, 2021.osf.io/fp9ym (https://osf.io/fp9ym/). Lippincott Williams & Wilkins 2021-08-06 /pmc/articles/PMC8341341/ /pubmed/34397791 http://dx.doi.org/10.1097/MD.0000000000026402 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 3900
Li, Jie
Hu, Fei-Yan
Zhong, Guo
Clinical therapeutic effects of opioid analgesia for acute abdominal pain in children and young adults: A protocol for systematic review and meta-analysis
title Clinical therapeutic effects of opioid analgesia for acute abdominal pain in children and young adults: A protocol for systematic review and meta-analysis
title_full Clinical therapeutic effects of opioid analgesia for acute abdominal pain in children and young adults: A protocol for systematic review and meta-analysis
title_fullStr Clinical therapeutic effects of opioid analgesia for acute abdominal pain in children and young adults: A protocol for systematic review and meta-analysis
title_full_unstemmed Clinical therapeutic effects of opioid analgesia for acute abdominal pain in children and young adults: A protocol for systematic review and meta-analysis
title_short Clinical therapeutic effects of opioid analgesia for acute abdominal pain in children and young adults: A protocol for systematic review and meta-analysis
title_sort clinical therapeutic effects of opioid analgesia for acute abdominal pain in children and young adults: a protocol for systematic review and meta-analysis
topic 3900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341341/
https://www.ncbi.nlm.nih.gov/pubmed/34397791
http://dx.doi.org/10.1097/MD.0000000000026402
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