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Diagnostic accuracy of interleukin-33 for tuberculous pleural effusion: A systematic review and meta-analysis

BACKGROUND: The detection of interleukin 33 (IL-33) in pleural effusion may be more sensitive in diagnosing tuberculous pleural effusion (TPE). The present study aimed to assess the accuracy of pleural IL-33 for the diagnosis of TPE by means of meta-analysis and systematic review of relevant studies...

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Autores principales: Shi, Xin-Yu, Yi, Feng-Shuang, Qiao, Xin, Pei, Xue-Bin, Dong, Shu-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341376/
https://www.ncbi.nlm.nih.gov/pubmed/34397818
http://dx.doi.org/10.1097/MD.0000000000026755
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author Shi, Xin-Yu
Yi, Feng-Shuang
Qiao, Xin
Pei, Xue-Bin
Dong, Shu-Feng
author_facet Shi, Xin-Yu
Yi, Feng-Shuang
Qiao, Xin
Pei, Xue-Bin
Dong, Shu-Feng
author_sort Shi, Xin-Yu
collection PubMed
description BACKGROUND: The detection of interleukin 33 (IL-33) in pleural effusion may be more sensitive in diagnosing tuberculous pleural effusion (TPE). The present study aimed to assess the accuracy of pleural IL-33 for the diagnosis of TPE by means of meta-analysis and systematic review of relevant studies. METHOD: After retrieving the published studies, the sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and a summary receiver operating characteristic curve were assessed to estimate the usefulness of pleural IL-33 in diagnosing TPE using meta-analysis with a random-effects model. We also performed meta-regression and subgroup analysis. RESULTS: A total of 639 patients from 6 studies were analyzed. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 0.87 (95% confidence interval [CI], 0.82–0.91), 0.76 (95% CI, 0.72–0.80), 6.54 (95% CI, 2.65–16.15), 0.17 (95% CI, 0.10–1.27), and 45.40 (95% CI, 12.83–160.70) respectively. The area under the curve was 0.94. The composition of the included population was the main cause of heterogeneity and subgroup analysis showed that pleural IL-33 had a higher specificity (0.93, 95% CI 0.87–0.96) when used for differential diagnosis between TPE and malignant pleural effusion. CONCLUSION: The detection of IL-33 alone in pleural effusion seems to not be an efficient diagnostic marker for TPE but may serve as a novel biomarker to differentiate between TPE and malignant pleural effusion.
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spelling pubmed-83413762021-08-07 Diagnostic accuracy of interleukin-33 for tuberculous pleural effusion: A systematic review and meta-analysis Shi, Xin-Yu Yi, Feng-Shuang Qiao, Xin Pei, Xue-Bin Dong, Shu-Feng Medicine (Baltimore) 6700 BACKGROUND: The detection of interleukin 33 (IL-33) in pleural effusion may be more sensitive in diagnosing tuberculous pleural effusion (TPE). The present study aimed to assess the accuracy of pleural IL-33 for the diagnosis of TPE by means of meta-analysis and systematic review of relevant studies. METHOD: After retrieving the published studies, the sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and a summary receiver operating characteristic curve were assessed to estimate the usefulness of pleural IL-33 in diagnosing TPE using meta-analysis with a random-effects model. We also performed meta-regression and subgroup analysis. RESULTS: A total of 639 patients from 6 studies were analyzed. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 0.87 (95% confidence interval [CI], 0.82–0.91), 0.76 (95% CI, 0.72–0.80), 6.54 (95% CI, 2.65–16.15), 0.17 (95% CI, 0.10–1.27), and 45.40 (95% CI, 12.83–160.70) respectively. The area under the curve was 0.94. The composition of the included population was the main cause of heterogeneity and subgroup analysis showed that pleural IL-33 had a higher specificity (0.93, 95% CI 0.87–0.96) when used for differential diagnosis between TPE and malignant pleural effusion. CONCLUSION: The detection of IL-33 alone in pleural effusion seems to not be an efficient diagnostic marker for TPE but may serve as a novel biomarker to differentiate between TPE and malignant pleural effusion. Lippincott Williams & Wilkins 2021-08-06 /pmc/articles/PMC8341376/ /pubmed/34397818 http://dx.doi.org/10.1097/MD.0000000000026755 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 6700
Shi, Xin-Yu
Yi, Feng-Shuang
Qiao, Xin
Pei, Xue-Bin
Dong, Shu-Feng
Diagnostic accuracy of interleukin-33 for tuberculous pleural effusion: A systematic review and meta-analysis
title Diagnostic accuracy of interleukin-33 for tuberculous pleural effusion: A systematic review and meta-analysis
title_full Diagnostic accuracy of interleukin-33 for tuberculous pleural effusion: A systematic review and meta-analysis
title_fullStr Diagnostic accuracy of interleukin-33 for tuberculous pleural effusion: A systematic review and meta-analysis
title_full_unstemmed Diagnostic accuracy of interleukin-33 for tuberculous pleural effusion: A systematic review and meta-analysis
title_short Diagnostic accuracy of interleukin-33 for tuberculous pleural effusion: A systematic review and meta-analysis
title_sort diagnostic accuracy of interleukin-33 for tuberculous pleural effusion: a systematic review and meta-analysis
topic 6700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341376/
https://www.ncbi.nlm.nih.gov/pubmed/34397818
http://dx.doi.org/10.1097/MD.0000000000026755
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