Hepatocyte membrane potential regulates serum insulin and insulin sensitivity by altering hepatic GABA release

Hepatic lipid accumulation in obesity correlates with the severity of hyperinsulinemia and systemic insulin resistance. Obesity-induced hepatocellular lipid accumulation results in hepatocyte depolarization. We have established that hepatocyte depolarization depresses hepatic afferent vagal nerve fi...

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Detalles Bibliográficos
Autores principales: Geisler, Caroline E., Ghimire, Susma, Hepler, Chelsea, Miller, Kendra E., Bruggink, Stephanie M., Kentch, Kyle P., Higgins, Mark R., Banek, Christopher T., Yoshino, Jun, Klein, Samuel, Renquist, Benjamin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341405/
https://www.ncbi.nlm.nih.gov/pubmed/34192533
http://dx.doi.org/10.1016/j.celrep.2021.109298

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