Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain

Stapled peptides are promising protein–protein interaction (PPI) inhibitors that can increase the binding potency. Different from small-molecule inhibitors in which the binding mainly depends on energetic interactions with their protein targets, the binding of stapled peptides has long been suggeste...

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Detalles Bibliográficos
Autores principales: Unarta, Ilona Christy, Xu, Jianchao, Shang, Yuan, Cheung, Carina Hey Pui, Zhu, Ruichi, Chen, Xudong, Cao, Siqin, Cheung, Peter Pak-Hang, Bierer, Donald, Zhang, Mingjie, Huang, Xuhui, Li, Xuechen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341669/
https://www.ncbi.nlm.nih.gov/pubmed/34458841
http://dx.doi.org/10.1039/d1cb00087j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341669/
https://www.ncbi.nlm.nih.gov/pubmed/34458841
http://dx.doi.org/10.1039/d1cb00087j

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