Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein

Prions are infectious proteins causing fatal, transmissible neurodegenerative diseases of animals and humans. Replication involves template-directed refolding of host encoded prion protein, PrP(C), by its infectious conformation, PrP(Sc). Following its discovery in captive Colorado deer in 1967, unc...

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Detalles Bibliográficos
Autores principales: Bian, Jifeng, Kim, Sehun, Kane, Sarah J., Crowell, Jenna, Sun, Julianna L., Christiansen, Jeffrey, Saijo, Eri, Moreno, Julie A., DiLisio, James, Burnett, Emily, Pritzkow, Sandra, Gorski, Damian, Soto, Claudio, Kreeger, Terry J., Balachandran, Aru, Mitchell, Gordon, Miller, Michael W., Nonno, Romolo, Vikøren, Turid, Våge, Jørn, Madslien, Knut, Tran, Linh, Vuong, Tram Thu, Benestad, Sylvie L., Telling, Glenn C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341702/
https://www.ncbi.nlm.nih.gov/pubmed/34310663
http://dx.doi.org/10.1371/journal.ppat.1009748

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