Neuroinvasiveness of the MR766 strain of Zika virus in IFNAR(-/-) mice maps to prM residues conserved amongst African genotype viruses

Zika virus (ZIKV) strains are classified into the African and Asian genotypes. The higher virulence of the African MR766 strain, which has been used extensively in ZIKV research, in adult IFNα/β receptor knockout (IFNAR(-/-)) mice is widely viewed as an artifact associated with mouse adaptation due...

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Detalles Bibliográficos
Autores principales: Nakayama, Eri, Kato, Fumihiro, Tajima, Shigeru, Ogawa, Shinya, Yan, Kexin, Takahashi, Kenta, Sato, Yuko, Suzuki, Tadaki, Kawai, Yasuhiro, Inagaki, Takuya, Taniguchi, Satoshi, Le, Thuy T., Tang, Bing, Prow, Natalie A., Uda, Akihiko, Maeki, Takahiro, Lim, Chang-Kweng, Khromykh, Alexander A., Suhrbier, Andreas, Saijo, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341709/
https://www.ncbi.nlm.nih.gov/pubmed/34310650
http://dx.doi.org/10.1371/journal.ppat.1009788

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