Aggregation of protein therapeutics enhances their immunogenicity: causes and mitigation strategies

Protein aggregation in biotherapeutics has been identified to increase immunogenicity, leading to immune-mediated adverse effects, such as severe allergic responses including anaphylaxis. The induction of anti-drug antibodies (ADAs) moreover enhances drug clearance rates, and can directly block ther...

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Detalles Bibliográficos
Autores principales: Lundahl, Mimmi L. E., Fogli, Silvia, Colavita, Paula E., Scanlan, Eoin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341748/
https://www.ncbi.nlm.nih.gov/pubmed/34458822
http://dx.doi.org/10.1039/d1cb00067e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341748/
https://www.ncbi.nlm.nih.gov/pubmed/34458822
http://dx.doi.org/10.1039/d1cb00067e

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