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Aggregation of protein therapeutics enhances their immunogenicity: causes and mitigation strategies
Protein aggregation in biotherapeutics has been identified to increase immunogenicity, leading to immune-mediated adverse effects, such as severe allergic responses including anaphylaxis. The induction of anti-drug antibodies (ADAs) moreover enhances drug clearance rates, and can directly block ther...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
RSC
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341748/ https://www.ncbi.nlm.nih.gov/pubmed/34458822 http://dx.doi.org/10.1039/d1cb00067e |