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White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression

More than one-third of depressive patients do not achieve remission after the first antidepressant treatment. The “watch and wait” approach used to find the most effective antidepressant leads to an increased personal, social, and economic burden in society. In order to overcome this challenge, ther...

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Autores principales: Vieira, Rita, Coelho, Ana, Reis, Joana, Portugal-Nunes, Carlos, Magalhães, Ricardo, Ferreira, Sónia, Moreira, Pedro Silva, Sousa, Nuno, Bessa, João M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341904/
https://www.ncbi.nlm.nih.gov/pubmed/34366806
http://dx.doi.org/10.3389/fnbeh.2021.693109
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author Vieira, Rita
Coelho, Ana
Reis, Joana
Portugal-Nunes, Carlos
Magalhães, Ricardo
Ferreira, Sónia
Moreira, Pedro Silva
Sousa, Nuno
Bessa, João M.
author_facet Vieira, Rita
Coelho, Ana
Reis, Joana
Portugal-Nunes, Carlos
Magalhães, Ricardo
Ferreira, Sónia
Moreira, Pedro Silva
Sousa, Nuno
Bessa, João M.
author_sort Vieira, Rita
collection PubMed
description More than one-third of depressive patients do not achieve remission after the first antidepressant treatment. The “watch and wait” approach used to find the most effective antidepressant leads to an increased personal, social, and economic burden in society. In order to overcome this challenge, there has been a focus on studying neural biomarkers associated with antidepressant response. Diffusion tensor imaging measures have shown a promising role as predictors of antidepressant response by pointing to pretreatment differences in the white matter microstructural integrity between future responders and non-responders to different pharmacotherapies. Therefore, the aim of the present study was to explore whether response to paroxetine treatment was associated with differences in the white matter microstructure at baseline. Twenty drug-naive patients diagnosed with major depressive disorder followed a 6- to 12-week treatment with paroxetine. All patients completed magnetic resonance brain imaging and a clinical assessment at baseline and 6–12 weeks after treatment. Whole-brain tract-based spatial statistics was used to explore differences in white matter microstructural properties estimated from diffusion magnetic resonance imaging. Voxel-wise statistical analysis revealed a significant increase in fractional anisotropy and a decrease in radial diffusivity in forceps minor and superior longitudinal fasciculus in responders compared to non-responders. Thus, alterations in white matter integrity, specifically in forceps minor and the superior longitudinal fasciculus, are associated with paroxetine treatment response. These findings pave the way for personalized treatment strategies in major depression.
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spelling pubmed-83419042021-08-06 White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression Vieira, Rita Coelho, Ana Reis, Joana Portugal-Nunes, Carlos Magalhães, Ricardo Ferreira, Sónia Moreira, Pedro Silva Sousa, Nuno Bessa, João M. Front Behav Neurosci Behavioral Neuroscience More than one-third of depressive patients do not achieve remission after the first antidepressant treatment. The “watch and wait” approach used to find the most effective antidepressant leads to an increased personal, social, and economic burden in society. In order to overcome this challenge, there has been a focus on studying neural biomarkers associated with antidepressant response. Diffusion tensor imaging measures have shown a promising role as predictors of antidepressant response by pointing to pretreatment differences in the white matter microstructural integrity between future responders and non-responders to different pharmacotherapies. Therefore, the aim of the present study was to explore whether response to paroxetine treatment was associated with differences in the white matter microstructure at baseline. Twenty drug-naive patients diagnosed with major depressive disorder followed a 6- to 12-week treatment with paroxetine. All patients completed magnetic resonance brain imaging and a clinical assessment at baseline and 6–12 weeks after treatment. Whole-brain tract-based spatial statistics was used to explore differences in white matter microstructural properties estimated from diffusion magnetic resonance imaging. Voxel-wise statistical analysis revealed a significant increase in fractional anisotropy and a decrease in radial diffusivity in forceps minor and superior longitudinal fasciculus in responders compared to non-responders. Thus, alterations in white matter integrity, specifically in forceps minor and the superior longitudinal fasciculus, are associated with paroxetine treatment response. These findings pave the way for personalized treatment strategies in major depression. Frontiers Media S.A. 2021-07-22 /pmc/articles/PMC8341904/ /pubmed/34366806 http://dx.doi.org/10.3389/fnbeh.2021.693109 Text en Copyright © 2021 Vieira, Coelho, Reis, Portugal-Nunes, Magalhães, Ferreira, Moreira, Sousa and Bessa. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Behavioral Neuroscience
Vieira, Rita
Coelho, Ana
Reis, Joana
Portugal-Nunes, Carlos
Magalhães, Ricardo
Ferreira, Sónia
Moreira, Pedro Silva
Sousa, Nuno
Bessa, João M.
White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression
title White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression
title_full White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression
title_fullStr White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression
title_full_unstemmed White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression
title_short White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression
title_sort white matter microstructure alterations associated with paroxetine treatment response in major depression
topic Behavioral Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341904/
https://www.ncbi.nlm.nih.gov/pubmed/34366806
http://dx.doi.org/10.3389/fnbeh.2021.693109
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