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Recent developments and applications of quantitative proteomics strategies for high-throughput biomolecular analyses in cancer research

Innovations in medical technology and dedicated focus from the scientific community have inspired numerous treatment strategies for benign and invasive cancers. While these improvements often lend themselves to more positive prognoses and greater patient longevity, means for early detection and seve...

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Detalles Bibliográficos
Autores principales: Miles, Hannah N., Delafield, Daniel G., Li, Lingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341969/
https://www.ncbi.nlm.nih.gov/pubmed/34430874
http://dx.doi.org/10.1039/d1cb00039j
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author Miles, Hannah N.
Delafield, Daniel G.
Li, Lingjun
author_facet Miles, Hannah N.
Delafield, Daniel G.
Li, Lingjun
author_sort Miles, Hannah N.
collection PubMed
description Innovations in medical technology and dedicated focus from the scientific community have inspired numerous treatment strategies for benign and invasive cancers. While these improvements often lend themselves to more positive prognoses and greater patient longevity, means for early detection and severity stratification have failed to keep pace. Detection and validation of cancer-specific biomarkers hinges on the ability to identify subtype-specific phenotypic and proteomic alterations and the systematic screening of diverse patient groups. For this reason, clinical and scientific research settings rely on high throughput and high sensitivity mass spectrometry methods to discover and quantify unique molecular perturbations in cancer patients. Discussed within is an overview of quantitative proteomics strategies and a summary of recent applications that enable revealing potential biomarkers and treatment targets in prostate, ovarian, breast, and pancreatic cancer in a high throughput manner.
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spelling pubmed-83419692021-08-23 Recent developments and applications of quantitative proteomics strategies for high-throughput biomolecular analyses in cancer research Miles, Hannah N. Delafield, Daniel G. Li, Lingjun RSC Chem Biol Chemistry Innovations in medical technology and dedicated focus from the scientific community have inspired numerous treatment strategies for benign and invasive cancers. While these improvements often lend themselves to more positive prognoses and greater patient longevity, means for early detection and severity stratification have failed to keep pace. Detection and validation of cancer-specific biomarkers hinges on the ability to identify subtype-specific phenotypic and proteomic alterations and the systematic screening of diverse patient groups. For this reason, clinical and scientific research settings rely on high throughput and high sensitivity mass spectrometry methods to discover and quantify unique molecular perturbations in cancer patients. Discussed within is an overview of quantitative proteomics strategies and a summary of recent applications that enable revealing potential biomarkers and treatment targets in prostate, ovarian, breast, and pancreatic cancer in a high throughput manner. RSC 2021-05-19 /pmc/articles/PMC8341969/ /pubmed/34430874 http://dx.doi.org/10.1039/d1cb00039j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Miles, Hannah N.
Delafield, Daniel G.
Li, Lingjun
Recent developments and applications of quantitative proteomics strategies for high-throughput biomolecular analyses in cancer research
title Recent developments and applications of quantitative proteomics strategies for high-throughput biomolecular analyses in cancer research
title_full Recent developments and applications of quantitative proteomics strategies for high-throughput biomolecular analyses in cancer research
title_fullStr Recent developments and applications of quantitative proteomics strategies for high-throughput biomolecular analyses in cancer research
title_full_unstemmed Recent developments and applications of quantitative proteomics strategies for high-throughput biomolecular analyses in cancer research
title_short Recent developments and applications of quantitative proteomics strategies for high-throughput biomolecular analyses in cancer research
title_sort recent developments and applications of quantitative proteomics strategies for high-throughput biomolecular analyses in cancer research
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341969/
https://www.ncbi.nlm.nih.gov/pubmed/34430874
http://dx.doi.org/10.1039/d1cb00039j
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