Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration

Sirtuin 2 (SIRT2) is a protein deacylase enzyme that removes acetyl groups and longer chain acyl groups from post-translationally modified lysine residues. It affects diverse biological functions in the cell and has been considered a drug target in relation to both neurodegenerative diseases and can...

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Detalles Bibliográficos
Autores principales: Nielsen, Alexander L., Rajabi, Nima, Kudo, Norio, Lundø, Kathrine, Moreno-Yruela, Carlos, Bæk, Michael, Fontenas, Martin, Lucidi, Alessia, Madsen, Andreas S., Yoshida, Minoru, Olsen, Christian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341974/
https://www.ncbi.nlm.nih.gov/pubmed/34458803
http://dx.doi.org/10.1039/d0cb00036a

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