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Sex differences in postnatal weight gain trajectories of extremely preterm newborns

OBJECTIVE: Both postnatal growth and sex play a crucial role in long-term outcomes of extremely preterm newborns (EPNs), but the relationship between sex and postnatal growth is not clear. This study aims to assess sex differences in weight trajectories. STUDY DESIGN: Weight data in the first 200 da...

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Autores principales: Chou, Fu-Sheng, Yeh, Hung-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342307/
https://www.ncbi.nlm.nih.gov/pubmed/34035451
http://dx.doi.org/10.1038/s41372-021-01099-2
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author Chou, Fu-Sheng
Yeh, Hung-Wen
author_facet Chou, Fu-Sheng
Yeh, Hung-Wen
author_sort Chou, Fu-Sheng
collection PubMed
description OBJECTIVE: Both postnatal growth and sex play a crucial role in long-term outcomes of extremely preterm newborns (EPNs), but the relationship between sex and postnatal growth is not clear. This study aims to assess sex differences in weight trajectories. STUDY DESIGN: Weight data in the first 200 days of life from 4327 EPNs were used for generalized additive mixed modeling. We considered gestational age and sex as fixed-effects, and included random intercepts and random slopes for postnatal age. We assessed interactions between fixed-effects and postnatal age. RESULTS: Male EPNs had higher predicted weight trajectories than females. Weight z-score trajectories decreased in both sexes before term-equivalent age comparably, but females showed faster increases afterward. Although weight gain velocity was comparable between both sexes, weight gain velocity in male EPNs was lower compared to the corresponding reference values from the 2013 Fenton growth charts, which explained slower z-score rises. CONCLUSION: Sex disparity exists in postnatal weight gain trajectories of EPNs after reaching the term-equivalent age.
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spelling pubmed-83423072021-08-20 Sex differences in postnatal weight gain trajectories of extremely preterm newborns Chou, Fu-Sheng Yeh, Hung-Wen J Perinatol Article OBJECTIVE: Both postnatal growth and sex play a crucial role in long-term outcomes of extremely preterm newborns (EPNs), but the relationship between sex and postnatal growth is not clear. This study aims to assess sex differences in weight trajectories. STUDY DESIGN: Weight data in the first 200 days of life from 4327 EPNs were used for generalized additive mixed modeling. We considered gestational age and sex as fixed-effects, and included random intercepts and random slopes for postnatal age. We assessed interactions between fixed-effects and postnatal age. RESULTS: Male EPNs had higher predicted weight trajectories than females. Weight z-score trajectories decreased in both sexes before term-equivalent age comparably, but females showed faster increases afterward. Although weight gain velocity was comparable between both sexes, weight gain velocity in male EPNs was lower compared to the corresponding reference values from the 2013 Fenton growth charts, which explained slower z-score rises. CONCLUSION: Sex disparity exists in postnatal weight gain trajectories of EPNs after reaching the term-equivalent age. Nature Publishing Group US 2021-05-25 2021 /pmc/articles/PMC8342307/ /pubmed/34035451 http://dx.doi.org/10.1038/s41372-021-01099-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Chou, Fu-Sheng
Yeh, Hung-Wen
Sex differences in postnatal weight gain trajectories of extremely preterm newborns
title Sex differences in postnatal weight gain trajectories of extremely preterm newborns
title_full Sex differences in postnatal weight gain trajectories of extremely preterm newborns
title_fullStr Sex differences in postnatal weight gain trajectories of extremely preterm newborns
title_full_unstemmed Sex differences in postnatal weight gain trajectories of extremely preterm newborns
title_short Sex differences in postnatal weight gain trajectories of extremely preterm newborns
title_sort sex differences in postnatal weight gain trajectories of extremely preterm newborns
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342307/
https://www.ncbi.nlm.nih.gov/pubmed/34035451
http://dx.doi.org/10.1038/s41372-021-01099-2
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