Possible Preventative/Rehabilitative Role of Gliflozins in OSA and T2DM. A Systematic Literature Review-Based Hypothesis

Obstructive sleep apnoea (OSA) is characterized by frequent apnoea episodes during sleep due to upper airway obstruction. The present review summarizes current knowledge on inter-relationships between OSA and type 2 diabetes mellitus (T2DM) and suggests the former as a possible target for sodium-glu...

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Autores principales: Monda, Vincenzo Maria, Porcellati, Francesca, Strollo, Felice, Fucili, Alessandro, Monesi, Marcello, Satta, Ersilia, Gentile, Sandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342338/
https://www.ncbi.nlm.nih.gov/pubmed/34273093
http://dx.doi.org/10.1007/s12325-021-01791-x
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author Monda, Vincenzo Maria
Porcellati, Francesca
Strollo, Felice
Fucili, Alessandro
Monesi, Marcello
Satta, Ersilia
Gentile, Sandro
author_facet Monda, Vincenzo Maria
Porcellati, Francesca
Strollo, Felice
Fucili, Alessandro
Monesi, Marcello
Satta, Ersilia
Gentile, Sandro
author_sort Monda, Vincenzo Maria
collection PubMed
description Obstructive sleep apnoea (OSA) is characterized by frequent apnoea episodes during sleep due to upper airway obstruction. The present review summarizes current knowledge on inter-relationships between OSA and type 2 diabetes mellitus (T2DM) and suggests the former as a possible target for sodium-glucose co-transporter-2 inhibitors (SGLT-2i). Based on pathophysiological mechanisms underlying OSA onset and renal SGLT-2 effects, we suggest that SGLT-2i indications might expand beyond current ones, including glucose, lipids, uric acid, blood pressure, and body weight control as well as chronic heart failure and kidney disease prevention.
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spelling pubmed-83423382021-08-20 Possible Preventative/Rehabilitative Role of Gliflozins in OSA and T2DM. A Systematic Literature Review-Based Hypothesis Monda, Vincenzo Maria Porcellati, Francesca Strollo, Felice Fucili, Alessandro Monesi, Marcello Satta, Ersilia Gentile, Sandro Adv Ther Review Obstructive sleep apnoea (OSA) is characterized by frequent apnoea episodes during sleep due to upper airway obstruction. The present review summarizes current knowledge on inter-relationships between OSA and type 2 diabetes mellitus (T2DM) and suggests the former as a possible target for sodium-glucose co-transporter-2 inhibitors (SGLT-2i). Based on pathophysiological mechanisms underlying OSA onset and renal SGLT-2 effects, we suggest that SGLT-2i indications might expand beyond current ones, including glucose, lipids, uric acid, blood pressure, and body weight control as well as chronic heart failure and kidney disease prevention. Springer Healthcare 2021-07-17 2021 /pmc/articles/PMC8342338/ /pubmed/34273093 http://dx.doi.org/10.1007/s12325-021-01791-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Monda, Vincenzo Maria
Porcellati, Francesca
Strollo, Felice
Fucili, Alessandro
Monesi, Marcello
Satta, Ersilia
Gentile, Sandro
Possible Preventative/Rehabilitative Role of Gliflozins in OSA and T2DM. A Systematic Literature Review-Based Hypothesis
title Possible Preventative/Rehabilitative Role of Gliflozins in OSA and T2DM. A Systematic Literature Review-Based Hypothesis
title_full Possible Preventative/Rehabilitative Role of Gliflozins in OSA and T2DM. A Systematic Literature Review-Based Hypothesis
title_fullStr Possible Preventative/Rehabilitative Role of Gliflozins in OSA and T2DM. A Systematic Literature Review-Based Hypothesis
title_full_unstemmed Possible Preventative/Rehabilitative Role of Gliflozins in OSA and T2DM. A Systematic Literature Review-Based Hypothesis
title_short Possible Preventative/Rehabilitative Role of Gliflozins in OSA and T2DM. A Systematic Literature Review-Based Hypothesis
title_sort possible preventative/rehabilitative role of gliflozins in osa and t2dm. a systematic literature review-based hypothesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342338/
https://www.ncbi.nlm.nih.gov/pubmed/34273093
http://dx.doi.org/10.1007/s12325-021-01791-x
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