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Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients

Oxidative stress may accompany the pathological process in transient global amnesia (TGA). We measured the biological antioxidant potential (BAP) in the cerebrospinal fluid (CSF) of TGA patients. We enrolled 13 TGA patients (7 men, 6 women; mean age 65.0 years [48–70 years]) and 24 control subjects...

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Autores principales: Kawai, Takayuki, Sakakibara, Ryuji, Aiba, Yosuke, Tateno, Fuyuki, Ogata, Tsuyoshi, Sawai, Setsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342448/
https://www.ncbi.nlm.nih.gov/pubmed/34354147
http://dx.doi.org/10.1038/s41598-021-95343-6
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author Kawai, Takayuki
Sakakibara, Ryuji
Aiba, Yosuke
Tateno, Fuyuki
Ogata, Tsuyoshi
Sawai, Setsu
author_facet Kawai, Takayuki
Sakakibara, Ryuji
Aiba, Yosuke
Tateno, Fuyuki
Ogata, Tsuyoshi
Sawai, Setsu
author_sort Kawai, Takayuki
collection PubMed
description Oxidative stress may accompany the pathological process in transient global amnesia (TGA). We measured the biological antioxidant potential (BAP) in the cerebrospinal fluid (CSF) of TGA patients. We enrolled 13 TGA patients (7 men, 6 women; mean age 65.0 years [48–70 years]) and 24 control subjects (12 men, 12 women; mean age 38.2 years [17–65 years]; age did not correlate with csfBAP in this group). We performed brain MRI in all TGA patients, and CA1 lesions were noted by MRI in 5 subjects. We measured csfBAP, total antioxidant properties, in all TGA patients and controls. csfBAP levels were higher in TGA patients than in controls (p = 0.024, 0.028). csfBAP levels in TGA patients did not differ between MRI-positive and -negative subgroups. Elevated csfBAP levels were observed in TGA patients, suggesting that oxidative stress may have a role in the pathogenesis of TGA.
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spelling pubmed-83424482021-08-06 Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients Kawai, Takayuki Sakakibara, Ryuji Aiba, Yosuke Tateno, Fuyuki Ogata, Tsuyoshi Sawai, Setsu Sci Rep Article Oxidative stress may accompany the pathological process in transient global amnesia (TGA). We measured the biological antioxidant potential (BAP) in the cerebrospinal fluid (CSF) of TGA patients. We enrolled 13 TGA patients (7 men, 6 women; mean age 65.0 years [48–70 years]) and 24 control subjects (12 men, 12 women; mean age 38.2 years [17–65 years]; age did not correlate with csfBAP in this group). We performed brain MRI in all TGA patients, and CA1 lesions were noted by MRI in 5 subjects. We measured csfBAP, total antioxidant properties, in all TGA patients and controls. csfBAP levels were higher in TGA patients than in controls (p = 0.024, 0.028). csfBAP levels in TGA patients did not differ between MRI-positive and -negative subgroups. Elevated csfBAP levels were observed in TGA patients, suggesting that oxidative stress may have a role in the pathogenesis of TGA. Nature Publishing Group UK 2021-08-05 /pmc/articles/PMC8342448/ /pubmed/34354147 http://dx.doi.org/10.1038/s41598-021-95343-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kawai, Takayuki
Sakakibara, Ryuji
Aiba, Yosuke
Tateno, Fuyuki
Ogata, Tsuyoshi
Sawai, Setsu
Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients
title Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients
title_full Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients
title_fullStr Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients
title_full_unstemmed Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients
title_short Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients
title_sort increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342448/
https://www.ncbi.nlm.nih.gov/pubmed/34354147
http://dx.doi.org/10.1038/s41598-021-95343-6
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