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The effect of genetic polymorphisms on treatment duration following premolar extraction

To elucidate genetic factors affecting orthodontic treatment duration, we employed targeted next-generation sequencing on DNA from the saliva of 117 patients undergoing orthodontic treatment after premolar extraction. The clinical characteristics of patients are summarized, and the association of cl...

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Autores principales: Yu, Jiyon, Choi, Yoon Jeong, Choi, Sung-Hwan, Jung, Han-Sung, Lee, Ji Hyun, Cha, Jung-Yul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342496/
https://www.ncbi.nlm.nih.gov/pubmed/34354108
http://dx.doi.org/10.1038/s41598-021-94979-8
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author Yu, Jiyon
Choi, Yoon Jeong
Choi, Sung-Hwan
Jung, Han-Sung
Lee, Ji Hyun
Cha, Jung-Yul
author_facet Yu, Jiyon
Choi, Yoon Jeong
Choi, Sung-Hwan
Jung, Han-Sung
Lee, Ji Hyun
Cha, Jung-Yul
author_sort Yu, Jiyon
collection PubMed
description To elucidate genetic factors affecting orthodontic treatment duration, we employed targeted next-generation sequencing on DNA from the saliva of 117 patients undergoing orthodontic treatment after premolar extraction. The clinical characteristics of patients are summarized, and the association of clinical variables with treatment duration was assessed. Patients whose treatment duration deviated from the average were classified into an extreme long group or an extreme short group. We identified nine single nucleotide polymorphisms (SNPs) of six genes that significantly differed in the two groups via targeted sequencing. The frequency of the CC genotypes of WNT3A, SPP1 (rs4754, rs9138), and TNFSF11, TT genotype of SPP1 (rs1126616), and GG genotype of SFRP2 was significantly higher in the extreme long group than in the short group. In the extreme short group, the TC genotype of SPP1, AA genotype of P2RX7, CT genotype of TNFSF11, and AG genotype of TNFRSF11A tended to exhibit higher frequency than in the long group. Taken together, we identified genetic polymorphisms related to treatment duration in Korean orthodontic patients undergoing premolar extraction. Our findings could lead to further studies predicting the prolongation of the orthodontic treatment duration, and will be of great aid to patients as well as orthodontists.
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spelling pubmed-83424962021-08-06 The effect of genetic polymorphisms on treatment duration following premolar extraction Yu, Jiyon Choi, Yoon Jeong Choi, Sung-Hwan Jung, Han-Sung Lee, Ji Hyun Cha, Jung-Yul Sci Rep Article To elucidate genetic factors affecting orthodontic treatment duration, we employed targeted next-generation sequencing on DNA from the saliva of 117 patients undergoing orthodontic treatment after premolar extraction. The clinical characteristics of patients are summarized, and the association of clinical variables with treatment duration was assessed. Patients whose treatment duration deviated from the average were classified into an extreme long group or an extreme short group. We identified nine single nucleotide polymorphisms (SNPs) of six genes that significantly differed in the two groups via targeted sequencing. The frequency of the CC genotypes of WNT3A, SPP1 (rs4754, rs9138), and TNFSF11, TT genotype of SPP1 (rs1126616), and GG genotype of SFRP2 was significantly higher in the extreme long group than in the short group. In the extreme short group, the TC genotype of SPP1, AA genotype of P2RX7, CT genotype of TNFSF11, and AG genotype of TNFRSF11A tended to exhibit higher frequency than in the long group. Taken together, we identified genetic polymorphisms related to treatment duration in Korean orthodontic patients undergoing premolar extraction. Our findings could lead to further studies predicting the prolongation of the orthodontic treatment duration, and will be of great aid to patients as well as orthodontists. Nature Publishing Group UK 2021-08-05 /pmc/articles/PMC8342496/ /pubmed/34354108 http://dx.doi.org/10.1038/s41598-021-94979-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yu, Jiyon
Choi, Yoon Jeong
Choi, Sung-Hwan
Jung, Han-Sung
Lee, Ji Hyun
Cha, Jung-Yul
The effect of genetic polymorphisms on treatment duration following premolar extraction
title The effect of genetic polymorphisms on treatment duration following premolar extraction
title_full The effect of genetic polymorphisms on treatment duration following premolar extraction
title_fullStr The effect of genetic polymorphisms on treatment duration following premolar extraction
title_full_unstemmed The effect of genetic polymorphisms on treatment duration following premolar extraction
title_short The effect of genetic polymorphisms on treatment duration following premolar extraction
title_sort effect of genetic polymorphisms on treatment duration following premolar extraction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342496/
https://www.ncbi.nlm.nih.gov/pubmed/34354108
http://dx.doi.org/10.1038/s41598-021-94979-8
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