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Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations

The use of antimalarial drugs is an effective strategy in the fight against malaria. However, selection of drug resistant parasites is a constant threat to the continued use of this approach. Antimalarial drugs are used not only to treat infections but also as part of population-level strategies to...

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Autores principales: Ndiaye, Yaye Die, Hartl, Daniel L., McGregor, David, Badiane, Aida, Fall, Fatou Ba, Daniels, Rachel F., Wirth, Dyann F., Ndiaye, Daouda, Volkman, Sarah K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342550/
https://www.ncbi.nlm.nih.gov/pubmed/34333350
http://dx.doi.org/10.1016/j.ijpddr.2021.07.004
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author Ndiaye, Yaye Die
Hartl, Daniel L.
McGregor, David
Badiane, Aida
Fall, Fatou Ba
Daniels, Rachel F.
Wirth, Dyann F.
Ndiaye, Daouda
Volkman, Sarah K.
author_facet Ndiaye, Yaye Die
Hartl, Daniel L.
McGregor, David
Badiane, Aida
Fall, Fatou Ba
Daniels, Rachel F.
Wirth, Dyann F.
Ndiaye, Daouda
Volkman, Sarah K.
author_sort Ndiaye, Yaye Die
collection PubMed
description The use of antimalarial drugs is an effective strategy in the fight against malaria. However, selection of drug resistant parasites is a constant threat to the continued use of this approach. Antimalarial drugs are used not only to treat infections but also as part of population-level strategies to reduce malaria transmission toward elimination. While there is strong evidence that the ongoing use of antimalarial drugs increases the risk of the emergence and spread of drug-resistant parasites, it is less clear how population-level use of drug-based interventions like seasonal malaria chemoprevention (SMC) or mass drug administration (MDA) may contribute to drug resistance or loss of drug efficacy. Critical to sustained use of drug-based strategies for reducing the burden of malaria is the surveillance of population-level signals related to transmission reduction and resistance selection. Here we focus on Plasmodium falciparum and discuss the genetic signatures of a parasite population that are correlated with changes in transmission and related to drug pressure and resistance as a result of drug use. We review the evidence for MDA and SMC contributing to malaria burden reduction and drug resistance selection and examine the use and impact of these interventions in Senegal. Throughout we consider best strategies for ongoing surveillance of both population and resistance signals in the context of different parasite population parameters. Finally, we propose a roadmap for ongoing surveillance during population-level drug-based interventions to reduce the global malaria burden.
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spelling pubmed-83425502021-08-11 Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations Ndiaye, Yaye Die Hartl, Daniel L. McGregor, David Badiane, Aida Fall, Fatou Ba Daniels, Rachel F. Wirth, Dyann F. Ndiaye, Daouda Volkman, Sarah K. Int J Parasitol Drugs Drug Resist Special issue articles on 'Drug Resistance - Mechanisms, Surveillance and Parasite Populations' The use of antimalarial drugs is an effective strategy in the fight against malaria. However, selection of drug resistant parasites is a constant threat to the continued use of this approach. Antimalarial drugs are used not only to treat infections but also as part of population-level strategies to reduce malaria transmission toward elimination. While there is strong evidence that the ongoing use of antimalarial drugs increases the risk of the emergence and spread of drug-resistant parasites, it is less clear how population-level use of drug-based interventions like seasonal malaria chemoprevention (SMC) or mass drug administration (MDA) may contribute to drug resistance or loss of drug efficacy. Critical to sustained use of drug-based strategies for reducing the burden of malaria is the surveillance of population-level signals related to transmission reduction and resistance selection. Here we focus on Plasmodium falciparum and discuss the genetic signatures of a parasite population that are correlated with changes in transmission and related to drug pressure and resistance as a result of drug use. We review the evidence for MDA and SMC contributing to malaria burden reduction and drug resistance selection and examine the use and impact of these interventions in Senegal. Throughout we consider best strategies for ongoing surveillance of both population and resistance signals in the context of different parasite population parameters. Finally, we propose a roadmap for ongoing surveillance during population-level drug-based interventions to reduce the global malaria burden. Elsevier 2021-07-26 /pmc/articles/PMC8342550/ /pubmed/34333350 http://dx.doi.org/10.1016/j.ijpddr.2021.07.004 Text en © 2021 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Special issue articles on 'Drug Resistance - Mechanisms, Surveillance and Parasite Populations'
Ndiaye, Yaye Die
Hartl, Daniel L.
McGregor, David
Badiane, Aida
Fall, Fatou Ba
Daniels, Rachel F.
Wirth, Dyann F.
Ndiaye, Daouda
Volkman, Sarah K.
Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations
title Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations
title_full Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations
title_fullStr Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations
title_full_unstemmed Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations
title_short Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations
title_sort genetic surveillance for monitoring the impact of drug use on plasmodium falciparum populations
topic Special issue articles on 'Drug Resistance - Mechanisms, Surveillance and Parasite Populations'
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342550/
https://www.ncbi.nlm.nih.gov/pubmed/34333350
http://dx.doi.org/10.1016/j.ijpddr.2021.07.004
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