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National Biosafety Management System: A Combined Framework Approach Based on 15 Key Elements

The pervasive nature of infections causing major outbreaks have elevated biosafety and biosecurity as a fundamental component for resilient national laboratory systems. In response to international health security demands, the Global Health Security Agenda emphasizes biosafety as one of the prerequi...

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Autores principales: Orelle, Arnaud, Nikiema, Abdoulaye, Zakaryan, Arsen, Albetkova, Adilya A., Rayfield, Mark A., Peruski, Leonard F., Pierson, Antoine, Kachuwaire, Obert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342751/
https://www.ncbi.nlm.nih.gov/pubmed/34368035
http://dx.doi.org/10.3389/fpubh.2021.609107
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author Orelle, Arnaud
Nikiema, Abdoulaye
Zakaryan, Arsen
Albetkova, Adilya A.
Rayfield, Mark A.
Peruski, Leonard F.
Pierson, Antoine
Kachuwaire, Obert
author_facet Orelle, Arnaud
Nikiema, Abdoulaye
Zakaryan, Arsen
Albetkova, Adilya A.
Rayfield, Mark A.
Peruski, Leonard F.
Pierson, Antoine
Kachuwaire, Obert
author_sort Orelle, Arnaud
collection PubMed
description The pervasive nature of infections causing major outbreaks have elevated biosafety and biosecurity as a fundamental component for resilient national laboratory systems. In response to international health security demands, the Global Health Security Agenda emphasizes biosafety as one of the prerequisites to respond effectively to infectious disease threats. However, biosafety management systems (BMS) in low-medium income countries (LMIC) remain weak due to fragmented implementation strategies. In addition, inefficiencies in implementation have been due to limited resources, inadequate technical expertise, high equipment costs, and insufficient political will. Here we propose an approach to developing a strong, self-sustaining BMS based on extensive experience in LMICs. A conceptual framework incorporating 15 key components to guide implementers, national laboratory leaders, global health security experts in building a BMS is presented. This conceptual framework provides a holistic and logical approach to the development of a BMS with all critical elements. It includes a flexible planning matrix with timelines easily adaptable to different country contexts as examples, as well as resources that are critical for developing sustainable technical expertise.
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spelling pubmed-83427512021-08-07 National Biosafety Management System: A Combined Framework Approach Based on 15 Key Elements Orelle, Arnaud Nikiema, Abdoulaye Zakaryan, Arsen Albetkova, Adilya A. Rayfield, Mark A. Peruski, Leonard F. Pierson, Antoine Kachuwaire, Obert Front Public Health Public Health The pervasive nature of infections causing major outbreaks have elevated biosafety and biosecurity as a fundamental component for resilient national laboratory systems. In response to international health security demands, the Global Health Security Agenda emphasizes biosafety as one of the prerequisites to respond effectively to infectious disease threats. However, biosafety management systems (BMS) in low-medium income countries (LMIC) remain weak due to fragmented implementation strategies. In addition, inefficiencies in implementation have been due to limited resources, inadequate technical expertise, high equipment costs, and insufficient political will. Here we propose an approach to developing a strong, self-sustaining BMS based on extensive experience in LMICs. A conceptual framework incorporating 15 key components to guide implementers, national laboratory leaders, global health security experts in building a BMS is presented. This conceptual framework provides a holistic and logical approach to the development of a BMS with all critical elements. It includes a flexible planning matrix with timelines easily adaptable to different country contexts as examples, as well as resources that are critical for developing sustainable technical expertise. Frontiers Media S.A. 2021-07-23 /pmc/articles/PMC8342751/ /pubmed/34368035 http://dx.doi.org/10.3389/fpubh.2021.609107 Text en Copyright © 2021 Orelle, Nikiema, Zakaryan, Albetkova, Rayfield, Peruski, Pierson and Kachuwaire. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Orelle, Arnaud
Nikiema, Abdoulaye
Zakaryan, Arsen
Albetkova, Adilya A.
Rayfield, Mark A.
Peruski, Leonard F.
Pierson, Antoine
Kachuwaire, Obert
National Biosafety Management System: A Combined Framework Approach Based on 15 Key Elements
title National Biosafety Management System: A Combined Framework Approach Based on 15 Key Elements
title_full National Biosafety Management System: A Combined Framework Approach Based on 15 Key Elements
title_fullStr National Biosafety Management System: A Combined Framework Approach Based on 15 Key Elements
title_full_unstemmed National Biosafety Management System: A Combined Framework Approach Based on 15 Key Elements
title_short National Biosafety Management System: A Combined Framework Approach Based on 15 Key Elements
title_sort national biosafety management system: a combined framework approach based on 15 key elements
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342751/
https://www.ncbi.nlm.nih.gov/pubmed/34368035
http://dx.doi.org/10.3389/fpubh.2021.609107
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