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Research('s) Sweet Hearts: Experimental Biomedical Models of Diabetic Cardiomyopathy

Diabetes and the often accompanying cardiovascular diseases including cardiomyopathy represent a complex disease, that is reluctant to reveal the molecular mechanisms and underlying cellular responses. Current research projects on diabetic cardiomyopathy are predominantly based on animal models, in...

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Detalles Bibliográficos
Autores principales: Richter, Claudia, Hinkel, Rabea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342758/
https://www.ncbi.nlm.nih.gov/pubmed/34368257
http://dx.doi.org/10.3389/fcvm.2021.703355
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author Richter, Claudia
Hinkel, Rabea
author_facet Richter, Claudia
Hinkel, Rabea
author_sort Richter, Claudia
collection PubMed
description Diabetes and the often accompanying cardiovascular diseases including cardiomyopathy represent a complex disease, that is reluctant to reveal the molecular mechanisms and underlying cellular responses. Current research projects on diabetic cardiomyopathy are predominantly based on animal models, in which there are not only obvious advantages, such as genetics that can be traced over generations and the directly measurable influence of dietary types, but also not despisable disadvantages. Thus, many studies are built up on transgenic rodent models, which are partly comparable to symptoms in humans due to their genetic alterations, but on the other hand are also under discussion regarding their clinical relevance in the translation of biomedical therapeutic approaches. Furthermore, a focus on transgenic rodent models ignores spontaneously occurring diabetes in larger mammals (such as dogs or pigs), which represent with their anatomical similarity to humans regarding their cardiovascular situation appealing models for testing translational approaches. With this in mind, we aim to shed light on the currently most popular animal models for diabetic cardiomyopathy and, by weighing the advantages and disadvantages, provide decision support for future animal experimental work in the field, hence advancing the biomedical translation of promising approaches into clinical application.
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spelling pubmed-83427582021-08-07 Research('s) Sweet Hearts: Experimental Biomedical Models of Diabetic Cardiomyopathy Richter, Claudia Hinkel, Rabea Front Cardiovasc Med Cardiovascular Medicine Diabetes and the often accompanying cardiovascular diseases including cardiomyopathy represent a complex disease, that is reluctant to reveal the molecular mechanisms and underlying cellular responses. Current research projects on diabetic cardiomyopathy are predominantly based on animal models, in which there are not only obvious advantages, such as genetics that can be traced over generations and the directly measurable influence of dietary types, but also not despisable disadvantages. Thus, many studies are built up on transgenic rodent models, which are partly comparable to symptoms in humans due to their genetic alterations, but on the other hand are also under discussion regarding their clinical relevance in the translation of biomedical therapeutic approaches. Furthermore, a focus on transgenic rodent models ignores spontaneously occurring diabetes in larger mammals (such as dogs or pigs), which represent with their anatomical similarity to humans regarding their cardiovascular situation appealing models for testing translational approaches. With this in mind, we aim to shed light on the currently most popular animal models for diabetic cardiomyopathy and, by weighing the advantages and disadvantages, provide decision support for future animal experimental work in the field, hence advancing the biomedical translation of promising approaches into clinical application. Frontiers Media S.A. 2021-07-23 /pmc/articles/PMC8342758/ /pubmed/34368257 http://dx.doi.org/10.3389/fcvm.2021.703355 Text en Copyright © 2021 Richter and Hinkel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Richter, Claudia
Hinkel, Rabea
Research('s) Sweet Hearts: Experimental Biomedical Models of Diabetic Cardiomyopathy
title Research('s) Sweet Hearts: Experimental Biomedical Models of Diabetic Cardiomyopathy
title_full Research('s) Sweet Hearts: Experimental Biomedical Models of Diabetic Cardiomyopathy
title_fullStr Research('s) Sweet Hearts: Experimental Biomedical Models of Diabetic Cardiomyopathy
title_full_unstemmed Research('s) Sweet Hearts: Experimental Biomedical Models of Diabetic Cardiomyopathy
title_short Research('s) Sweet Hearts: Experimental Biomedical Models of Diabetic Cardiomyopathy
title_sort research('s) sweet hearts: experimental biomedical models of diabetic cardiomyopathy
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342758/
https://www.ncbi.nlm.nih.gov/pubmed/34368257
http://dx.doi.org/10.3389/fcvm.2021.703355
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