The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt

TBK1 responds to microbes to initiate cellular responses critical for host innate immune defense. We found previously that TBK1 phosphorylates mTOR (mechanistic target of rapamycin) on S2159 to increase mTOR complex 1 (mTORC1) signaling in response to the growth factor EGF and the viral dsRNA mimeti...

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Detalles Bibliográficos
Autores principales: Tooley, Aaron Seth, Kazyken, Dubek, Bodur, Cagri, Gonzalez, Ian E., Fingar, Diane C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342794/
https://www.ncbi.nlm.nih.gov/pubmed/34245780
http://dx.doi.org/10.1016/j.jbc.2021.100942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342794/
https://www.ncbi.nlm.nih.gov/pubmed/34245780
http://dx.doi.org/10.1016/j.jbc.2021.100942

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