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Nitration of protein kinase G-Iα modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injury

Phosphodiesterase 3A (PDE3A) selectively cleaves the phosphodiester bond of cAMP and is inhibited by cGMP, making it an important regulator of cAMP–cGMP signaling crosstalk in the pulmonary vasculature. In addition, the nitric oxide–cGMP axis is known to play an important role in maintaining endothe...

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Detalles Bibliográficos
Autores principales:	Zemskov, Evgeny A., Wu, Xiaomin, Aggarwal, Saurabh, Yegambaram, Mannivannan, Gross, Christine, Lu, Qing, Wang, Hui, Tang, Haiyang, Wang, Ting, Black, Stephen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342797/ https://www.ncbi.nlm.nih.gov/pubmed/34252457 http://dx.doi.org/10.1016/j.jbc.2021.100946

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