Cargando…
Considerations for crossover design in clinical study
This article introduces a crossover design that is often used in clinical studies, with the advantage of comparing treatment effects within one study subject. In particular, the advantages and disadvantages of the two-period, two-sequence crossover design (2 × 2 or AB/BA crossover design), which is...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Anesthesiologists
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342834/ https://www.ncbi.nlm.nih.gov/pubmed/34344139 http://dx.doi.org/10.4097/kja.21165 |
_version_ | 1783734145088749568 |
---|---|
author | Lim, Chi-Yeon In, Junyong |
author_facet | Lim, Chi-Yeon In, Junyong |
author_sort | Lim, Chi-Yeon |
collection | PubMed |
description | This article introduces a crossover design that is often used in clinical studies, with the advantage of comparing treatment effects within one study subject. In particular, the advantages and disadvantages of the two-period, two-sequence crossover design (2 × 2 or AB/BA crossover design), which is widely used in clinical practice, are identified, and the elements necessary for analysis are introduced. This article explains the carryover effect, period effect, sequence effect, and period-by-treatment interaction in a crossover design and examines the analysis commands of SAS along with example data. After confirming the carryover effect using a general linear model, the treatment effect is analyzed using a linear mixed effect model. |
format | Online Article Text |
id | pubmed-8342834 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Society of Anesthesiologists |
record_format | MEDLINE/PubMed |
spelling | pubmed-83428342021-08-11 Considerations for crossover design in clinical study Lim, Chi-Yeon In, Junyong Korean J Anesthesiol Statistical Round This article introduces a crossover design that is often used in clinical studies, with the advantage of comparing treatment effects within one study subject. In particular, the advantages and disadvantages of the two-period, two-sequence crossover design (2 × 2 or AB/BA crossover design), which is widely used in clinical practice, are identified, and the elements necessary for analysis are introduced. This article explains the carryover effect, period effect, sequence effect, and period-by-treatment interaction in a crossover design and examines the analysis commands of SAS along with example data. After confirming the carryover effect using a general linear model, the treatment effect is analyzed using a linear mixed effect model. Korean Society of Anesthesiologists 2021-08 2021-07-30 /pmc/articles/PMC8342834/ /pubmed/34344139 http://dx.doi.org/10.4097/kja.21165 Text en Copyright © The Korean Society of Anesthesiologists, 2021 https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Statistical Round Lim, Chi-Yeon In, Junyong Considerations for crossover design in clinical study |
title | Considerations for crossover design in clinical study |
title_full | Considerations for crossover design in clinical study |
title_fullStr | Considerations for crossover design in clinical study |
title_full_unstemmed | Considerations for crossover design in clinical study |
title_short | Considerations for crossover design in clinical study |
title_sort | considerations for crossover design in clinical study |
topic | Statistical Round |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342834/ https://www.ncbi.nlm.nih.gov/pubmed/34344139 http://dx.doi.org/10.4097/kja.21165 |
work_keys_str_mv | AT limchiyeon considerationsforcrossoverdesigninclinicalstudy AT injunyong considerationsforcrossoverdesigninclinicalstudy |