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Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis

BACKGROUND: Antibiotic resistance is associated with longer hospitalizations, higher treatment costs, and increased morbidity and mortality rates. PURPOSE: This study aimed to determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in Iranian children. METHODS: International d...

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Autores principales: Sarrafzadeh, Farhad, Sohrevardi, Seyed Mojtaba, Abousaidi, Hamid, Mirzaei, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Pediatric Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342872/
https://www.ncbi.nlm.nih.gov/pubmed/33227182
http://dx.doi.org/10.3345/cep.2020.00255
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author Sarrafzadeh, Farhad
Sohrevardi, Seyed Mojtaba
Abousaidi, Hamid
Mirzaei, Hossein
author_facet Sarrafzadeh, Farhad
Sohrevardi, Seyed Mojtaba
Abousaidi, Hamid
Mirzaei, Hossein
author_sort Sarrafzadeh, Farhad
collection PubMed
description BACKGROUND: Antibiotic resistance is associated with longer hospitalizations, higher treatment costs, and increased morbidity and mortality rates. PURPOSE: This study aimed to determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in Iranian children. METHODS: International databases, including Web of Science, PubMed, Embase, and Scopus, and Iranian databases, including Scientific Information Database (www.sid.ir), Magiran, and Iranian Database for Medical Literature (idml.research.ac.ir), were systematically searched for articles published between January 2000 and August 2019. Sources of heterogeneity were determined using subgroup analysis and meta-regression. RESULTS: Overall, 343 studies were identified; of them, 20 were included in the meta-analysis to estimate the pooled prevalence. The pooled prevalence of MRSA was 42% (95% confidence interval [CI], 29–55) among culture-positive cases of S. aureus, 51% (95% CI, 39–62) in hospitalized children, and 14% (95% CI, 0.05–27) in healthy children. CONCLUSION: The overall pooled prevalence of MRSA in children was 42%. Appropriate infection control measures and effective antibiotic therapy are needed.
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spelling pubmed-83428722021-08-12 Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis Sarrafzadeh, Farhad Sohrevardi, Seyed Mojtaba Abousaidi, Hamid Mirzaei, Hossein Clin Exp Pediatr Original Article BACKGROUND: Antibiotic resistance is associated with longer hospitalizations, higher treatment costs, and increased morbidity and mortality rates. PURPOSE: This study aimed to determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in Iranian children. METHODS: International databases, including Web of Science, PubMed, Embase, and Scopus, and Iranian databases, including Scientific Information Database (www.sid.ir), Magiran, and Iranian Database for Medical Literature (idml.research.ac.ir), were systematically searched for articles published between January 2000 and August 2019. Sources of heterogeneity were determined using subgroup analysis and meta-regression. RESULTS: Overall, 343 studies were identified; of them, 20 were included in the meta-analysis to estimate the pooled prevalence. The pooled prevalence of MRSA was 42% (95% confidence interval [CI], 29–55) among culture-positive cases of S. aureus, 51% (95% CI, 39–62) in hospitalized children, and 14% (95% CI, 0.05–27) in healthy children. CONCLUSION: The overall pooled prevalence of MRSA in children was 42%. Appropriate infection control measures and effective antibiotic therapy are needed. Korean Pediatric Society 2020-11-20 /pmc/articles/PMC8342872/ /pubmed/33227182 http://dx.doi.org/10.3345/cep.2020.00255 Text en Copyright © 2021 by The Korean Pediatric Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sarrafzadeh, Farhad
Sohrevardi, Seyed Mojtaba
Abousaidi, Hamid
Mirzaei, Hossein
Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis
title Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis
title_full Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis
title_fullStr Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis
title_full_unstemmed Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis
title_short Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis
title_sort prevalence of methicillin-resistant staphylococcus aureus in iranian children: a systematic review and meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342872/
https://www.ncbi.nlm.nih.gov/pubmed/33227182
http://dx.doi.org/10.3345/cep.2020.00255
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