Cargando…

N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses

N6-methyladenosine (m(6)A) is a ubiquitous RNA modification in eukaryotes. It plays important roles in the translocation, stabilization and translation of mRNA. Many recent studies have shown that the dysregulation of m(6)A modification is connected with diseases caused by pathogenic viruses, and st...

Descripción completa

Detalles Bibliográficos
Autores principales: Feng, Qianyu, Zhao, Hongwei, Xu, Lili, Xie, Zhengde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342946/
https://www.ncbi.nlm.nih.gov/pubmed/34368152
http://dx.doi.org/10.3389/fcell.2021.699997
_version_ 1783734171945926656
author Feng, Qianyu
Zhao, Hongwei
Xu, Lili
Xie, Zhengde
author_facet Feng, Qianyu
Zhao, Hongwei
Xu, Lili
Xie, Zhengde
author_sort Feng, Qianyu
collection PubMed
description N6-methyladenosine (m(6)A) is a ubiquitous RNA modification in eukaryotes. It plays important roles in the translocation, stabilization and translation of mRNA. Many recent studies have shown that the dysregulation of m(6)A modification is connected with diseases caused by pathogenic viruses, and studies on the role of m(6)A in virus-host interactions have shown that m(6)A plays a wide range of regulatory roles in the life cycle of viruses. Respiratory viruses are common pathogens that can impose a large disease burden on young children and elderly people. Here, we review the effects of m(6)A modification on respiratory virus replication and life cycle and host immunity against viruses.
format Online
Article
Text
id pubmed-8342946
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-83429462021-08-07 N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses Feng, Qianyu Zhao, Hongwei Xu, Lili Xie, Zhengde Front Cell Dev Biol Cell and Developmental Biology N6-methyladenosine (m(6)A) is a ubiquitous RNA modification in eukaryotes. It plays important roles in the translocation, stabilization and translation of mRNA. Many recent studies have shown that the dysregulation of m(6)A modification is connected with diseases caused by pathogenic viruses, and studies on the role of m(6)A in virus-host interactions have shown that m(6)A plays a wide range of regulatory roles in the life cycle of viruses. Respiratory viruses are common pathogens that can impose a large disease burden on young children and elderly people. Here, we review the effects of m(6)A modification on respiratory virus replication and life cycle and host immunity against viruses. Frontiers Media S.A. 2021-07-23 /pmc/articles/PMC8342946/ /pubmed/34368152 http://dx.doi.org/10.3389/fcell.2021.699997 Text en Copyright © 2021 Feng, Zhao, Xu and Xie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Feng, Qianyu
Zhao, Hongwei
Xu, Lili
Xie, Zhengde
N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses
title N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses
title_full N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses
title_fullStr N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses
title_full_unstemmed N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses
title_short N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses
title_sort n6-methyladenosine modification and its regulation of respiratory viruses
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342946/
https://www.ncbi.nlm.nih.gov/pubmed/34368152
http://dx.doi.org/10.3389/fcell.2021.699997
work_keys_str_mv AT fengqianyu n6methyladenosinemodificationanditsregulationofrespiratoryviruses
AT zhaohongwei n6methyladenosinemodificationanditsregulationofrespiratoryviruses
AT xulili n6methyladenosinemodificationanditsregulationofrespiratoryviruses
AT xiezhengde n6methyladenosinemodificationanditsregulationofrespiratoryviruses