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N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses
N6-methyladenosine (m(6)A) is a ubiquitous RNA modification in eukaryotes. It plays important roles in the translocation, stabilization and translation of mRNA. Many recent studies have shown that the dysregulation of m(6)A modification is connected with diseases caused by pathogenic viruses, and st...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342946/ https://www.ncbi.nlm.nih.gov/pubmed/34368152 http://dx.doi.org/10.3389/fcell.2021.699997 |
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author | Feng, Qianyu Zhao, Hongwei Xu, Lili Xie, Zhengde |
author_facet | Feng, Qianyu Zhao, Hongwei Xu, Lili Xie, Zhengde |
author_sort | Feng, Qianyu |
collection | PubMed |
description | N6-methyladenosine (m(6)A) is a ubiquitous RNA modification in eukaryotes. It plays important roles in the translocation, stabilization and translation of mRNA. Many recent studies have shown that the dysregulation of m(6)A modification is connected with diseases caused by pathogenic viruses, and studies on the role of m(6)A in virus-host interactions have shown that m(6)A plays a wide range of regulatory roles in the life cycle of viruses. Respiratory viruses are common pathogens that can impose a large disease burden on young children and elderly people. Here, we review the effects of m(6)A modification on respiratory virus replication and life cycle and host immunity against viruses. |
format | Online Article Text |
id | pubmed-8342946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83429462021-08-07 N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses Feng, Qianyu Zhao, Hongwei Xu, Lili Xie, Zhengde Front Cell Dev Biol Cell and Developmental Biology N6-methyladenosine (m(6)A) is a ubiquitous RNA modification in eukaryotes. It plays important roles in the translocation, stabilization and translation of mRNA. Many recent studies have shown that the dysregulation of m(6)A modification is connected with diseases caused by pathogenic viruses, and studies on the role of m(6)A in virus-host interactions have shown that m(6)A plays a wide range of regulatory roles in the life cycle of viruses. Respiratory viruses are common pathogens that can impose a large disease burden on young children and elderly people. Here, we review the effects of m(6)A modification on respiratory virus replication and life cycle and host immunity against viruses. Frontiers Media S.A. 2021-07-23 /pmc/articles/PMC8342946/ /pubmed/34368152 http://dx.doi.org/10.3389/fcell.2021.699997 Text en Copyright © 2021 Feng, Zhao, Xu and Xie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Feng, Qianyu Zhao, Hongwei Xu, Lili Xie, Zhengde N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses |
title | N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses |
title_full | N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses |
title_fullStr | N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses |
title_full_unstemmed | N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses |
title_short | N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses |
title_sort | n6-methyladenosine modification and its regulation of respiratory viruses |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342946/ https://www.ncbi.nlm.nih.gov/pubmed/34368152 http://dx.doi.org/10.3389/fcell.2021.699997 |
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