Cargando…

Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range

Interleukin (IL)-37 has an important function in limiting excessive inflammation. Its expression is increased in numerous inflammatory and autoimmune conditions and correlates with disease activity, suggesting it could have potential as a disease biomarker. Nevertheless, a reference range has yet to...

Descripción completa

Detalles Bibliográficos
Autores principales: Santarelli, Danielle M., Vincent, Fabien B., Rudloff, Ina, Nold-Petry, Claudia A., Nold, Marcel F., Russo, Marc A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343013/
https://www.ncbi.nlm.nih.gov/pubmed/34367169
http://dx.doi.org/10.3389/fimmu.2021.708425
_version_ 1783734187109384192
author Santarelli, Danielle M.
Vincent, Fabien B.
Rudloff, Ina
Nold-Petry, Claudia A.
Nold, Marcel F.
Russo, Marc A.
author_facet Santarelli, Danielle M.
Vincent, Fabien B.
Rudloff, Ina
Nold-Petry, Claudia A.
Nold, Marcel F.
Russo, Marc A.
author_sort Santarelli, Danielle M.
collection PubMed
description Interleukin (IL)-37 has an important function in limiting excessive inflammation. Its expression is increased in numerous inflammatory and autoimmune conditions and correlates with disease activity, suggesting it could have potential as a disease biomarker. Nevertheless, a reference range has yet to be determined. Our aim was to establish the first reference range of circulating IL-37 levels in healthy adult humans. PubMed was searched for studies reporting blood IL-37 concentrations in healthy adult subjects as measured by enzyme-linked immunosorbent assay. Nineteen studies were included in the analysis. Mean IL-37 levels were weighted by sample sizes, and weighted mean lower and upper levels ( ± 2SD of means) were calculated to provide a weighted mean and reference range. IL-37 levels were quantified in either serum or plasma from a total of 1035 (647 serum; 388 plasma) healthy subjects. The serum, plasma and combined matrix weighted means (reference ranges) were 72.9 (41.5 – 104.4) pg/mL, 83.9 (41.1 – 126.8) pg/mL, and 77.1 (41.4 – 112.8) pg/mL, respectively. There were no significant differences between serum and plasma means and upper and lower limits. Study means and upper IL-37 levels were significantly higher in Chinese population studies. From our analysis, a preliminary reference range for circulating IL-37 levels in healthy human adults has been established. In order to determine a reliable reference range for clinical application, large, prospective, multi-ethnic, healthy population studies are necessary. In addition, demographics, sample matrix, collection, processing and storage methods potentially affecting IL-37 detection levels should be thoroughly investigated.
format Online
Article
Text
id pubmed-8343013
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-83430132021-08-07 Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range Santarelli, Danielle M. Vincent, Fabien B. Rudloff, Ina Nold-Petry, Claudia A. Nold, Marcel F. Russo, Marc A. Front Immunol Immunology Interleukin (IL)-37 has an important function in limiting excessive inflammation. Its expression is increased in numerous inflammatory and autoimmune conditions and correlates with disease activity, suggesting it could have potential as a disease biomarker. Nevertheless, a reference range has yet to be determined. Our aim was to establish the first reference range of circulating IL-37 levels in healthy adult humans. PubMed was searched for studies reporting blood IL-37 concentrations in healthy adult subjects as measured by enzyme-linked immunosorbent assay. Nineteen studies were included in the analysis. Mean IL-37 levels were weighted by sample sizes, and weighted mean lower and upper levels ( ± 2SD of means) were calculated to provide a weighted mean and reference range. IL-37 levels were quantified in either serum or plasma from a total of 1035 (647 serum; 388 plasma) healthy subjects. The serum, plasma and combined matrix weighted means (reference ranges) were 72.9 (41.5 – 104.4) pg/mL, 83.9 (41.1 – 126.8) pg/mL, and 77.1 (41.4 – 112.8) pg/mL, respectively. There were no significant differences between serum and plasma means and upper and lower limits. Study means and upper IL-37 levels were significantly higher in Chinese population studies. From our analysis, a preliminary reference range for circulating IL-37 levels in healthy human adults has been established. In order to determine a reliable reference range for clinical application, large, prospective, multi-ethnic, healthy population studies are necessary. In addition, demographics, sample matrix, collection, processing and storage methods potentially affecting IL-37 detection levels should be thoroughly investigated. Frontiers Media S.A. 2021-07-23 /pmc/articles/PMC8343013/ /pubmed/34367169 http://dx.doi.org/10.3389/fimmu.2021.708425 Text en Copyright © 2021 Santarelli, Vincent, Rudloff, Nold-Petry, Nold and Russo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Santarelli, Danielle M.
Vincent, Fabien B.
Rudloff, Ina
Nold-Petry, Claudia A.
Nold, Marcel F.
Russo, Marc A.
Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range
title Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range
title_full Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range
title_fullStr Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range
title_full_unstemmed Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range
title_short Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range
title_sort circulating interleukin-37 levels in healthy adult humans – establishing a reference range
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343013/
https://www.ncbi.nlm.nih.gov/pubmed/34367169
http://dx.doi.org/10.3389/fimmu.2021.708425
work_keys_str_mv AT santarellidaniellem circulatinginterleukin37levelsinhealthyadulthumansestablishingareferencerange
AT vincentfabienb circulatinginterleukin37levelsinhealthyadulthumansestablishingareferencerange
AT rudloffina circulatinginterleukin37levelsinhealthyadulthumansestablishingareferencerange
AT noldpetryclaudiaa circulatinginterleukin37levelsinhealthyadulthumansestablishingareferencerange
AT noldmarcelf circulatinginterleukin37levelsinhealthyadulthumansestablishingareferencerange
AT russomarca circulatinginterleukin37levelsinhealthyadulthumansestablishingareferencerange