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The influence of the gut microbiota on the bioavailability of oral drugs

Due to its safety, convenience, low cost and good compliance, oral administration attracts lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory bioavailability in the gastrointestinal tract. One of the critical and most overlooked factors is the symbiotic gu...

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Detalles Bibliográficos
Autores principales: Zhang, Xintong, Han, Ying, Huang, Wei, Jin, Mingji, Gao, Zhonggao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343123/
https://www.ncbi.nlm.nih.gov/pubmed/34386321
http://dx.doi.org/10.1016/j.apsb.2020.09.013
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author Zhang, Xintong
Han, Ying
Huang, Wei
Jin, Mingji
Gao, Zhonggao
author_facet Zhang, Xintong
Han, Ying
Huang, Wei
Jin, Mingji
Gao, Zhonggao
author_sort Zhang, Xintong
collection PubMed
description Due to its safety, convenience, low cost and good compliance, oral administration attracts lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory bioavailability in the gastrointestinal tract. One of the critical and most overlooked factors is the symbiotic gut microbiota that can modulate the bioavailability of oral drugs by participating in the biotransformation of oral drugs, influencing the drug transport process and altering some gastrointestinal properties. In this review, we summarized the existing research investigating the possible relationship between the gut microbiota and the bioavailability of oral drugs, which may provide great ideas and useful instructions for the design of novel drug delivery systems or the achievement of personalized medicine.
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spelling pubmed-83431232021-08-11 The influence of the gut microbiota on the bioavailability of oral drugs Zhang, Xintong Han, Ying Huang, Wei Jin, Mingji Gao, Zhonggao Acta Pharm Sin B Review Due to its safety, convenience, low cost and good compliance, oral administration attracts lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory bioavailability in the gastrointestinal tract. One of the critical and most overlooked factors is the symbiotic gut microbiota that can modulate the bioavailability of oral drugs by participating in the biotransformation of oral drugs, influencing the drug transport process and altering some gastrointestinal properties. In this review, we summarized the existing research investigating the possible relationship between the gut microbiota and the bioavailability of oral drugs, which may provide great ideas and useful instructions for the design of novel drug delivery systems or the achievement of personalized medicine. Elsevier 2021-07 2020-09-28 /pmc/articles/PMC8343123/ /pubmed/34386321 http://dx.doi.org/10.1016/j.apsb.2020.09.013 Text en © 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Zhang, Xintong
Han, Ying
Huang, Wei
Jin, Mingji
Gao, Zhonggao
The influence of the gut microbiota on the bioavailability of oral drugs
title The influence of the gut microbiota on the bioavailability of oral drugs
title_full The influence of the gut microbiota on the bioavailability of oral drugs
title_fullStr The influence of the gut microbiota on the bioavailability of oral drugs
title_full_unstemmed The influence of the gut microbiota on the bioavailability of oral drugs
title_short The influence of the gut microbiota on the bioavailability of oral drugs
title_sort influence of the gut microbiota on the bioavailability of oral drugs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343123/
https://www.ncbi.nlm.nih.gov/pubmed/34386321
http://dx.doi.org/10.1016/j.apsb.2020.09.013
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