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Magnoflorine Alleviates “M1” Polarized Macrophage-Induced Intervertebral Disc Degeneration Through Repressing the HMGB1/Myd88/NF-κB Pathway and NLRP3 Inflammasome

Intervertebral disc degeneration (IDD) is related to the deterioration of nucleus pulposus (NP) cells due to hypertrophic differentiation and calcification. The imbalance of pro-inflammatory (M1 type) and anti-inflammatory (M2 type) macrophages contributes to maintaining tissue integrity. Here, we a...

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Detalles Bibliográficos
Autores principales:	Zhao, Feng, Guo, Zhenye, Hou, Fushan, Fan, Wei, Wu, Binqiang, Qian, Zhonglai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343137/ https://www.ncbi.nlm.nih.gov/pubmed/34366853 http://dx.doi.org/10.3389/fphar.2021.701087

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