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Discovery of 4-arylthiophene-3-carboxylic acid as inhibitor of ANO1 and its effect as analgesic agent

Anoctamin 1 (ANO1) is a kind of calcium-activated chloride channel involved in nerve depolarization. ANO1 inhibitors display significant analgesic activity by the local peripheral and intrathecal administration. In this study, several thiophenecarboxylic acid and benzoic acid derivatives were identi...

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Detalles Bibliográficos
Autores principales:	Wang, Yuxi, Gao, Jian, Zhao, Song, Song, Yan, Huang, Han, Zhu, Guiwang, Jiao, Peili, Xu, Xiangqing, Zhang, Guisen, Wang, Kewei, Zhang, Liangren, Liu, Zhenming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343189/ https://www.ncbi.nlm.nih.gov/pubmed/34386330 http://dx.doi.org/10.1016/j.apsb.2020.11.004

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