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Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence

Tumor recurrence after surgery is the main cause of treatment failure. However, the initial stage of recurrence is not easy to detect, and it is difficult to cure in the late stage. In order to improve the life quality of postoperative patients, an efficient synergistic immunotherapy was developed t...

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Autores principales: Zhang, Yingying, Wang, Tiange, Tian, Yu, Zhang, Chaonan, Ge, Kun, Zhang, Jinchao, Chang, Jin, Wang, Hanjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343192/
https://www.ncbi.nlm.nih.gov/pubmed/34386332
http://dx.doi.org/10.1016/j.apsb.2021.03.035
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author Zhang, Yingying
Wang, Tiange
Tian, Yu
Zhang, Chaonan
Ge, Kun
Zhang, Jinchao
Chang, Jin
Wang, Hanjie
author_facet Zhang, Yingying
Wang, Tiange
Tian, Yu
Zhang, Chaonan
Ge, Kun
Zhang, Jinchao
Chang, Jin
Wang, Hanjie
author_sort Zhang, Yingying
collection PubMed
description Tumor recurrence after surgery is the main cause of treatment failure. However, the initial stage of recurrence is not easy to detect, and it is difficult to cure in the late stage. In order to improve the life quality of postoperative patients, an efficient synergistic immunotherapy was developed to achieve early diagnosis and treatment of post-surgical tumor recurrence, simultaneously. In this paper, two kinds of theranostic agents based on gold nanorods (AuNRs) platform were prepared. AuNRs and quantum dots (QDs) in one agent was used for the detection of carcinoembryonic antigen (CEA), using fluorescence resonance energy transfer (FRET) technology to indicate the occurrence of in situ recurrence, while AuNRs in the other agent was used for photothermal therapy (PTT), together with anti-PDL1 mediated immunotherapy to alleviate the process of tumor metastasis. A series of assays indicated that this synergistic immunotherapy could induce tumor cell death and the increased generation of CD3(+)/CD4(+) T-lymphocytes and CD3(+)/CD8(+) T-lymphocytes. Besides, more immune factors (IL-2, IL-6, and IFN-γ) produced by synergistic immunotherapy were secreted than mono-immunotherapy. This cooperative immunotherapy strategy could be utilized for diagnosis and treatment of postoperative tumor recurrence at the same time, providing a new perspective for basic and clinical research.
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spelling pubmed-83431922021-08-11 Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence Zhang, Yingying Wang, Tiange Tian, Yu Zhang, Chaonan Ge, Kun Zhang, Jinchao Chang, Jin Wang, Hanjie Acta Pharm Sin B Original Article Tumor recurrence after surgery is the main cause of treatment failure. However, the initial stage of recurrence is not easy to detect, and it is difficult to cure in the late stage. In order to improve the life quality of postoperative patients, an efficient synergistic immunotherapy was developed to achieve early diagnosis and treatment of post-surgical tumor recurrence, simultaneously. In this paper, two kinds of theranostic agents based on gold nanorods (AuNRs) platform were prepared. AuNRs and quantum dots (QDs) in one agent was used for the detection of carcinoembryonic antigen (CEA), using fluorescence resonance energy transfer (FRET) technology to indicate the occurrence of in situ recurrence, while AuNRs in the other agent was used for photothermal therapy (PTT), together with anti-PDL1 mediated immunotherapy to alleviate the process of tumor metastasis. A series of assays indicated that this synergistic immunotherapy could induce tumor cell death and the increased generation of CD3(+)/CD4(+) T-lymphocytes and CD3(+)/CD8(+) T-lymphocytes. Besides, more immune factors (IL-2, IL-6, and IFN-γ) produced by synergistic immunotherapy were secreted than mono-immunotherapy. This cooperative immunotherapy strategy could be utilized for diagnosis and treatment of postoperative tumor recurrence at the same time, providing a new perspective for basic and clinical research. Elsevier 2021-07 2021-03-26 /pmc/articles/PMC8343192/ /pubmed/34386332 http://dx.doi.org/10.1016/j.apsb.2021.03.035 Text en © 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Zhang, Yingying
Wang, Tiange
Tian, Yu
Zhang, Chaonan
Ge, Kun
Zhang, Jinchao
Chang, Jin
Wang, Hanjie
Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence
title Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence
title_full Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence
title_fullStr Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence
title_full_unstemmed Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence
title_short Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence
title_sort gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343192/
https://www.ncbi.nlm.nih.gov/pubmed/34386332
http://dx.doi.org/10.1016/j.apsb.2021.03.035
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