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Axonal mRNA localization and local translation in neurodegenerative disease

The regulation of mRNA localization and local translation play vital roles in the maintenance of cellular structure and function. Many human neurodegenerative diseases, such as fragile X syndrome, amyotrophic lateral sclerosis, Alzheimer’s disease, and spinal muscular atrophy, have been characterize...

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Autores principales: Lu, Jin-Xin, Wang, Yang, Zhang, Yi-Jie, Shen, Mei-Fen, Li, Hai-Ying, Yu, Zheng-Quan, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343310/
https://www.ncbi.nlm.nih.gov/pubmed/33642365
http://dx.doi.org/10.4103/1673-5374.308074
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author Lu, Jin-Xin
Wang, Yang
Zhang, Yi-Jie
Shen, Mei-Fen
Li, Hai-Ying
Yu, Zheng-Quan
Chen, Gang
author_facet Lu, Jin-Xin
Wang, Yang
Zhang, Yi-Jie
Shen, Mei-Fen
Li, Hai-Ying
Yu, Zheng-Quan
Chen, Gang
author_sort Lu, Jin-Xin
collection PubMed
description The regulation of mRNA localization and local translation play vital roles in the maintenance of cellular structure and function. Many human neurodegenerative diseases, such as fragile X syndrome, amyotrophic lateral sclerosis, Alzheimer’s disease, and spinal muscular atrophy, have been characterized by pathological changes in neuronal axons, including abnormal mRNA translation, the loss of protein expression, or abnormal axon transport. Moreover, the same protein and mRNA molecules have been associated with variable functions in different diseases due to differences in their interaction networks. In this review, we briefly examine fragile X syndrome, amyotrophic lateral sclerosis, Alzheimer’s disease, and spinal muscular atrophy, with a focus on disease pathogenesis with regard to local mRNA translation and axon transport, suggesting possible treatment directions.
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spelling pubmed-83433102021-08-20 Axonal mRNA localization and local translation in neurodegenerative disease Lu, Jin-Xin Wang, Yang Zhang, Yi-Jie Shen, Mei-Fen Li, Hai-Ying Yu, Zheng-Quan Chen, Gang Neural Regen Res Review The regulation of mRNA localization and local translation play vital roles in the maintenance of cellular structure and function. Many human neurodegenerative diseases, such as fragile X syndrome, amyotrophic lateral sclerosis, Alzheimer’s disease, and spinal muscular atrophy, have been characterized by pathological changes in neuronal axons, including abnormal mRNA translation, the loss of protein expression, or abnormal axon transport. Moreover, the same protein and mRNA molecules have been associated with variable functions in different diseases due to differences in their interaction networks. In this review, we briefly examine fragile X syndrome, amyotrophic lateral sclerosis, Alzheimer’s disease, and spinal muscular atrophy, with a focus on disease pathogenesis with regard to local mRNA translation and axon transport, suggesting possible treatment directions. Wolters Kluwer - Medknow 2021-02-19 /pmc/articles/PMC8343310/ /pubmed/33642365 http://dx.doi.org/10.4103/1673-5374.308074 Text en Copyright: © 2021 Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Lu, Jin-Xin
Wang, Yang
Zhang, Yi-Jie
Shen, Mei-Fen
Li, Hai-Ying
Yu, Zheng-Quan
Chen, Gang
Axonal mRNA localization and local translation in neurodegenerative disease
title Axonal mRNA localization and local translation in neurodegenerative disease
title_full Axonal mRNA localization and local translation in neurodegenerative disease
title_fullStr Axonal mRNA localization and local translation in neurodegenerative disease
title_full_unstemmed Axonal mRNA localization and local translation in neurodegenerative disease
title_short Axonal mRNA localization and local translation in neurodegenerative disease
title_sort axonal mrna localization and local translation in neurodegenerative disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343310/
https://www.ncbi.nlm.nih.gov/pubmed/33642365
http://dx.doi.org/10.4103/1673-5374.308074
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