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Axonal mRNA localization and local translation in neurodegenerative disease
The regulation of mRNA localization and local translation play vital roles in the maintenance of cellular structure and function. Many human neurodegenerative diseases, such as fragile X syndrome, amyotrophic lateral sclerosis, Alzheimer’s disease, and spinal muscular atrophy, have been characterize...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343310/ https://www.ncbi.nlm.nih.gov/pubmed/33642365 http://dx.doi.org/10.4103/1673-5374.308074 |
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author | Lu, Jin-Xin Wang, Yang Zhang, Yi-Jie Shen, Mei-Fen Li, Hai-Ying Yu, Zheng-Quan Chen, Gang |
author_facet | Lu, Jin-Xin Wang, Yang Zhang, Yi-Jie Shen, Mei-Fen Li, Hai-Ying Yu, Zheng-Quan Chen, Gang |
author_sort | Lu, Jin-Xin |
collection | PubMed |
description | The regulation of mRNA localization and local translation play vital roles in the maintenance of cellular structure and function. Many human neurodegenerative diseases, such as fragile X syndrome, amyotrophic lateral sclerosis, Alzheimer’s disease, and spinal muscular atrophy, have been characterized by pathological changes in neuronal axons, including abnormal mRNA translation, the loss of protein expression, or abnormal axon transport. Moreover, the same protein and mRNA molecules have been associated with variable functions in different diseases due to differences in their interaction networks. In this review, we briefly examine fragile X syndrome, amyotrophic lateral sclerosis, Alzheimer’s disease, and spinal muscular atrophy, with a focus on disease pathogenesis with regard to local mRNA translation and axon transport, suggesting possible treatment directions. |
format | Online Article Text |
id | pubmed-8343310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-83433102021-08-20 Axonal mRNA localization and local translation in neurodegenerative disease Lu, Jin-Xin Wang, Yang Zhang, Yi-Jie Shen, Mei-Fen Li, Hai-Ying Yu, Zheng-Quan Chen, Gang Neural Regen Res Review The regulation of mRNA localization and local translation play vital roles in the maintenance of cellular structure and function. Many human neurodegenerative diseases, such as fragile X syndrome, amyotrophic lateral sclerosis, Alzheimer’s disease, and spinal muscular atrophy, have been characterized by pathological changes in neuronal axons, including abnormal mRNA translation, the loss of protein expression, or abnormal axon transport. Moreover, the same protein and mRNA molecules have been associated with variable functions in different diseases due to differences in their interaction networks. In this review, we briefly examine fragile X syndrome, amyotrophic lateral sclerosis, Alzheimer’s disease, and spinal muscular atrophy, with a focus on disease pathogenesis with regard to local mRNA translation and axon transport, suggesting possible treatment directions. Wolters Kluwer - Medknow 2021-02-19 /pmc/articles/PMC8343310/ /pubmed/33642365 http://dx.doi.org/10.4103/1673-5374.308074 Text en Copyright: © 2021 Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Lu, Jin-Xin Wang, Yang Zhang, Yi-Jie Shen, Mei-Fen Li, Hai-Ying Yu, Zheng-Quan Chen, Gang Axonal mRNA localization and local translation in neurodegenerative disease |
title | Axonal mRNA localization and local translation in neurodegenerative disease |
title_full | Axonal mRNA localization and local translation in neurodegenerative disease |
title_fullStr | Axonal mRNA localization and local translation in neurodegenerative disease |
title_full_unstemmed | Axonal mRNA localization and local translation in neurodegenerative disease |
title_short | Axonal mRNA localization and local translation in neurodegenerative disease |
title_sort | axonal mrna localization and local translation in neurodegenerative disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343310/ https://www.ncbi.nlm.nih.gov/pubmed/33642365 http://dx.doi.org/10.4103/1673-5374.308074 |
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