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Liposomes and mRNA: Two technologies together create a COVID-19 vaccine

The urgency to understand and modify immune responses has never been as great universally as during the present Coronavirus time. It has been suggested that using established techniques, a small piece of the so-called spike protein of the Coronavirus injected into humans in the form of mRNA could ra...

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Detalles Bibliográficos
Autor principal: Gregoriadis, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343385/
http://dx.doi.org/10.1016/j.medidd.2021.100104
Descripción
Sumario:The urgency to understand and modify immune responses has never been as great universally as during the present Coronavirus time. It has been suggested that using established techniques, a small piece of the so-called spike protein of the Coronavirus injected into humans in the form of mRNA could raise an immune response against the expressed protein, in turn killing or inactivating the invading Coronavirus. Unfortunately, however, the mRNA was found to be too vulnerable to survive in the body long enough on injection to produce the spike protein and an immune response to it. But as it happens, a solution was to hand, one waiting to be discovered.