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Liposomes and mRNA: Two technologies together create a COVID-19 vaccine

The urgency to understand and modify immune responses has never been as great universally as during the present Coronavirus time. It has been suggested that using established techniques, a small piece of the so-called spike protein of the Coronavirus injected into humans in the form of mRNA could ra...

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Autor principal: Gregoriadis, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343385/
http://dx.doi.org/10.1016/j.medidd.2021.100104
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author Gregoriadis, Gregory
author_facet Gregoriadis, Gregory
author_sort Gregoriadis, Gregory
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description The urgency to understand and modify immune responses has never been as great universally as during the present Coronavirus time. It has been suggested that using established techniques, a small piece of the so-called spike protein of the Coronavirus injected into humans in the form of mRNA could raise an immune response against the expressed protein, in turn killing or inactivating the invading Coronavirus. Unfortunately, however, the mRNA was found to be too vulnerable to survive in the body long enough on injection to produce the spike protein and an immune response to it. But as it happens, a solution was to hand, one waiting to be discovered.
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spelling pubmed-83433852021-08-06 Liposomes and mRNA: Two technologies together create a COVID-19 vaccine Gregoriadis, Gregory Med Drug Discov Perspective The urgency to understand and modify immune responses has never been as great universally as during the present Coronavirus time. It has been suggested that using established techniques, a small piece of the so-called spike protein of the Coronavirus injected into humans in the form of mRNA could raise an immune response against the expressed protein, in turn killing or inactivating the invading Coronavirus. Unfortunately, however, the mRNA was found to be too vulnerable to survive in the body long enough on injection to produce the spike protein and an immune response to it. But as it happens, a solution was to hand, one waiting to be discovered. Elsevier B.V 2021-12 2021-08-06 /pmc/articles/PMC8343385/ http://dx.doi.org/10.1016/j.medidd.2021.100104 Text en Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Perspective
Gregoriadis, Gregory
Liposomes and mRNA: Two technologies together create a COVID-19 vaccine
title Liposomes and mRNA: Two technologies together create a COVID-19 vaccine
title_full Liposomes and mRNA: Two technologies together create a COVID-19 vaccine
title_fullStr Liposomes and mRNA: Two technologies together create a COVID-19 vaccine
title_full_unstemmed Liposomes and mRNA: Two technologies together create a COVID-19 vaccine
title_short Liposomes and mRNA: Two technologies together create a COVID-19 vaccine
title_sort liposomes and mrna: two technologies together create a covid-19 vaccine
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343385/
http://dx.doi.org/10.1016/j.medidd.2021.100104
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