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Prenatal findings and pregnancy outcome in fetuses with right and double aortic arch. A 10-year experience at a tertiary center

Objective: Our objective was to evaluate the accuracy of the prenatal diagnosis and the relation between the type of right aortic arch (RAA) with other intra- or extracardiac (EC) and chromosomal anomalies. Methods: A retrospective, observational study was conducted between 2011–2020 in a Romanian t...

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Autores principales: Petrescu, Ana-Maria, Ruican, Dan, Pătru, Ciprian Laurenţiu, Zorilă, George Lucian, Tudorache, Ştefania, Comănescu, Alexandru Cristian, Istrate-Ofiţeru, Anca-Maria, Badiu, Anne Marie, Ioana, Mihai, Stoica, George Alin, Iliescu, Dominic Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343474/
https://www.ncbi.nlm.nih.gov/pubmed/34171066
http://dx.doi.org/10.47162/RJME.61.4.19
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author Petrescu, Ana-Maria
Ruican, Dan
Pătru, Ciprian Laurenţiu
Zorilă, George Lucian
Tudorache, Ştefania
Comănescu, Alexandru Cristian
Istrate-Ofiţeru, Anca-Maria
Badiu, Anne Marie
Ioana, Mihai
Stoica, George Alin
Iliescu, Dominic Gabriel
author_facet Petrescu, Ana-Maria
Ruican, Dan
Pătru, Ciprian Laurenţiu
Zorilă, George Lucian
Tudorache, Ştefania
Comănescu, Alexandru Cristian
Istrate-Ofiţeru, Anca-Maria
Badiu, Anne Marie
Ioana, Mihai
Stoica, George Alin
Iliescu, Dominic Gabriel
author_sort Petrescu, Ana-Maria
collection PubMed
description Objective: Our objective was to evaluate the accuracy of the prenatal diagnosis and the relation between the type of right aortic arch (RAA) with other intra- or extracardiac (EC) and chromosomal anomalies. Methods: A retrospective, observational study was conducted between 2011–2020 in a Romanian tertiary center. All RAA cases, including double aortic arch (DAA), were extracted from the databases and studied thoroughly. Results: We detected 18 RAA cases: five (27.78%) type I (mirror image, “V” type), 11 (61.12%) type II (“U” type), and two (11.10%) DAA cases. Heart anomalies were associated in 38.89% (overall), 60% (type I), 36.37% (type II), and 0% (DAA) cases. Tetralogy of Fallot represented the most prevalent cardiac malformation (in 22.23% of cases). EC anomalies were present in 44.44% of fetuses (20% of type I, 54.55% of type II, and 50% of DAA cases). Genetic abnormalities were found in 41.17% of pregnancies, with 22q11.2 deletion in 23.53%. 55.55% of the cases had a good neonatal evolution and 44.45% of the pregnancies were terminated. An overall good outcome of pregnancy was noted in 40% of type I RAA, 63.64% of type II RAA, and 50% of DAA cases. All RAA cases examined in the first trimester were correctly diagnosed. Conclusions: RAA can be accurately diagnosed and classified by means of prenatal ultrasound since early pregnancy. A detailed anatomy scan and genetic testing, including 22q11 deletion, should be offered to all pregnancies when RAA is discovered. When isolated, RAA associates a good outcome, indifferently the anatomical type.
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spelling pubmed-83434742021-08-18 Prenatal findings and pregnancy outcome in fetuses with right and double aortic arch. A 10-year experience at a tertiary center Petrescu, Ana-Maria Ruican, Dan Pătru, Ciprian Laurenţiu Zorilă, George Lucian Tudorache, Ştefania Comănescu, Alexandru Cristian Istrate-Ofiţeru, Anca-Maria Badiu, Anne Marie Ioana, Mihai Stoica, George Alin Iliescu, Dominic Gabriel Rom J Morphol Embryol Original Paper Objective: Our objective was to evaluate the accuracy of the prenatal diagnosis and the relation between the type of right aortic arch (RAA) with other intra- or extracardiac (EC) and chromosomal anomalies. Methods: A retrospective, observational study was conducted between 2011–2020 in a Romanian tertiary center. All RAA cases, including double aortic arch (DAA), were extracted from the databases and studied thoroughly. Results: We detected 18 RAA cases: five (27.78%) type I (mirror image, “V” type), 11 (61.12%) type II (“U” type), and two (11.10%) DAA cases. Heart anomalies were associated in 38.89% (overall), 60% (type I), 36.37% (type II), and 0% (DAA) cases. Tetralogy of Fallot represented the most prevalent cardiac malformation (in 22.23% of cases). EC anomalies were present in 44.44% of fetuses (20% of type I, 54.55% of type II, and 50% of DAA cases). Genetic abnormalities were found in 41.17% of pregnancies, with 22q11.2 deletion in 23.53%. 55.55% of the cases had a good neonatal evolution and 44.45% of the pregnancies were terminated. An overall good outcome of pregnancy was noted in 40% of type I RAA, 63.64% of type II RAA, and 50% of DAA cases. All RAA cases examined in the first trimester were correctly diagnosed. Conclusions: RAA can be accurately diagnosed and classified by means of prenatal ultrasound since early pregnancy. A detailed anatomy scan and genetic testing, including 22q11 deletion, should be offered to all pregnancies when RAA is discovered. When isolated, RAA associates a good outcome, indifferently the anatomical type. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020 2021-05-27 /pmc/articles/PMC8343474/ /pubmed/34171066 http://dx.doi.org/10.47162/RJME.61.4.19 Text en Copyright © 2020, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
Petrescu, Ana-Maria
Ruican, Dan
Pătru, Ciprian Laurenţiu
Zorilă, George Lucian
Tudorache, Ştefania
Comănescu, Alexandru Cristian
Istrate-Ofiţeru, Anca-Maria
Badiu, Anne Marie
Ioana, Mihai
Stoica, George Alin
Iliescu, Dominic Gabriel
Prenatal findings and pregnancy outcome in fetuses with right and double aortic arch. A 10-year experience at a tertiary center
title Prenatal findings and pregnancy outcome in fetuses with right and double aortic arch. A 10-year experience at a tertiary center
title_full Prenatal findings and pregnancy outcome in fetuses with right and double aortic arch. A 10-year experience at a tertiary center
title_fullStr Prenatal findings and pregnancy outcome in fetuses with right and double aortic arch. A 10-year experience at a tertiary center
title_full_unstemmed Prenatal findings and pregnancy outcome in fetuses with right and double aortic arch. A 10-year experience at a tertiary center
title_short Prenatal findings and pregnancy outcome in fetuses with right and double aortic arch. A 10-year experience at a tertiary center
title_sort prenatal findings and pregnancy outcome in fetuses with right and double aortic arch. a 10-year experience at a tertiary center
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343474/
https://www.ncbi.nlm.nih.gov/pubmed/34171066
http://dx.doi.org/10.47162/RJME.61.4.19
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