Cargando…

Gastric cancer – histopathological correlations between tumor and non-tumor gastric mucosa changes

Gastric cancer is a widely geographically distributed malignancy with high prevalence, therefore being a serious health problem that needs standardized methods for early diagnosis and treatment. The aim of the study was to evaluate the correlation of some epidemiological and clinical data with the h...

Descripción completa

Detalles Bibliográficos
Autores principales: Păun, Ion, Costin, Andrei Ionuţ, Constantin, Vlad Denis, Lomaca, Ion, Ianoşi, Nicolae Gabriel, Socea, Bogdan, Tutunaru, Cristina Violeta, Zlatian, Ovidiu Mircea, Ianoşi, Simona Laura, Neagoe, Carmen Daniela, Crafciuc, Antoanela Valentina, Stancu, Marius Ionuţ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343497/
https://www.ncbi.nlm.nih.gov/pubmed/34171062
http://dx.doi.org/10.47162/RJME.61.4.15
_version_ 1783734301164044288
author Păun, Ion
Costin, Andrei Ionuţ
Constantin, Vlad Denis
Lomaca, Ion
Ianoşi, Nicolae Gabriel
Socea, Bogdan
Tutunaru, Cristina Violeta
Zlatian, Ovidiu Mircea
Ianoşi, Simona Laura
Neagoe, Carmen Daniela
Crafciuc, Antoanela Valentina
Stancu, Marius Ionuţ
author_facet Păun, Ion
Costin, Andrei Ionuţ
Constantin, Vlad Denis
Lomaca, Ion
Ianoşi, Nicolae Gabriel
Socea, Bogdan
Tutunaru, Cristina Violeta
Zlatian, Ovidiu Mircea
Ianoşi, Simona Laura
Neagoe, Carmen Daniela
Crafciuc, Antoanela Valentina
Stancu, Marius Ionuţ
author_sort Păun, Ion
collection PubMed
description Gastric cancer is a widely geographically distributed malignancy with high prevalence, therefore being a serious health problem that needs standardized methods for early diagnosis and treatment. The aim of the study was to evaluate the correlation of some epidemiological and clinical data with the histological features. The study group was made up of 66 patients that underwent surgical removal of the gastric neoplasm, and the pathological exam showed the morphological features of the tumor, as well as the ones of the unaffected mucosal tissue. Topographically, the highest incidence of the tumor was registered in the gastric antrum, but in recent years, an increased incidence of the superior gastric pole localization was recorded. The macroscopic aspects reveal that the ulcerated type 2 Borrmann is the most frequent, and alongside type 3 Borrmann, the ulcer-infiltrative type represents most of the gastric antrum cancers. The analysis of the tumor invasion showed that most carcinomas underwent surgery when the tumor invaded the serosa (pT3) or even the perigastric tissues (pT4). In our research, we chose Goseki’s microscopic classification because of its best coverage of the histological heterogeneity of the gastric carcinomas, providing information about the percentage of the cellular and secretory differentiation with direct impact on the invasion of the tumor. In more than 70% of the cases, the patients showed lesions of severe chronic atrophic gastritis of the non-tumor mucosa. Lately, the incidence of Helicobacter pylori has been 5.5%, lower than indicated by mainstream literature. We observed that the incidence of type 3 incomplete intestinal metaplasia, as the most commonly involved factor in the etiopathogenesis of gastric neoplasms, was encountered in 36.3% of the cases, this percentage rising proportionally with age and being frequently associated with antrum tumors. In conclusion, the permanent analysis of the relation between epidemiological data and some histological features might be relevant for the characterization of the tumoral process or the non-tumor gastric mucosa, leading to an evaluation of the prognosis.
format Online
Article
Text
id pubmed-8343497
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest
record_format MEDLINE/PubMed
spelling pubmed-83434972021-08-18 Gastric cancer – histopathological correlations between tumor and non-tumor gastric mucosa changes Păun, Ion Costin, Andrei Ionuţ Constantin, Vlad Denis Lomaca, Ion Ianoşi, Nicolae Gabriel Socea, Bogdan Tutunaru, Cristina Violeta Zlatian, Ovidiu Mircea Ianoşi, Simona Laura Neagoe, Carmen Daniela Crafciuc, Antoanela Valentina Stancu, Marius Ionuţ Rom J Morphol Embryol Original Paper Gastric cancer is a widely geographically distributed malignancy with high prevalence, therefore being a serious health problem that needs standardized methods for early diagnosis and treatment. The aim of the study was to evaluate the correlation of some epidemiological and clinical data with the histological features. The study group was made up of 66 patients that underwent surgical removal of the gastric neoplasm, and the pathological exam showed the morphological features of the tumor, as well as the ones of the unaffected mucosal tissue. Topographically, the highest incidence of the tumor was registered in the gastric antrum, but in recent years, an increased incidence of the superior gastric pole localization was recorded. The macroscopic aspects reveal that the ulcerated type 2 Borrmann is the most frequent, and alongside type 3 Borrmann, the ulcer-infiltrative type represents most of the gastric antrum cancers. The analysis of the tumor invasion showed that most carcinomas underwent surgery when the tumor invaded the serosa (pT3) or even the perigastric tissues (pT4). In our research, we chose Goseki’s microscopic classification because of its best coverage of the histological heterogeneity of the gastric carcinomas, providing information about the percentage of the cellular and secretory differentiation with direct impact on the invasion of the tumor. In more than 70% of the cases, the patients showed lesions of severe chronic atrophic gastritis of the non-tumor mucosa. Lately, the incidence of Helicobacter pylori has been 5.5%, lower than indicated by mainstream literature. We observed that the incidence of type 3 incomplete intestinal metaplasia, as the most commonly involved factor in the etiopathogenesis of gastric neoplasms, was encountered in 36.3% of the cases, this percentage rising proportionally with age and being frequently associated with antrum tumors. In conclusion, the permanent analysis of the relation between epidemiological data and some histological features might be relevant for the characterization of the tumoral process or the non-tumor gastric mucosa, leading to an evaluation of the prognosis. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020 2021-06-23 /pmc/articles/PMC8343497/ /pubmed/34171062 http://dx.doi.org/10.47162/RJME.61.4.15 Text en Copyright © 2020, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
Păun, Ion
Costin, Andrei Ionuţ
Constantin, Vlad Denis
Lomaca, Ion
Ianoşi, Nicolae Gabriel
Socea, Bogdan
Tutunaru, Cristina Violeta
Zlatian, Ovidiu Mircea
Ianoşi, Simona Laura
Neagoe, Carmen Daniela
Crafciuc, Antoanela Valentina
Stancu, Marius Ionuţ
Gastric cancer – histopathological correlations between tumor and non-tumor gastric mucosa changes
title Gastric cancer – histopathological correlations between tumor and non-tumor gastric mucosa changes
title_full Gastric cancer – histopathological correlations between tumor and non-tumor gastric mucosa changes
title_fullStr Gastric cancer – histopathological correlations between tumor and non-tumor gastric mucosa changes
title_full_unstemmed Gastric cancer – histopathological correlations between tumor and non-tumor gastric mucosa changes
title_short Gastric cancer – histopathological correlations between tumor and non-tumor gastric mucosa changes
title_sort gastric cancer – histopathological correlations between tumor and non-tumor gastric mucosa changes
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343497/
https://www.ncbi.nlm.nih.gov/pubmed/34171062
http://dx.doi.org/10.47162/RJME.61.4.15
work_keys_str_mv AT paunion gastriccancerhistopathologicalcorrelationsbetweentumorandnontumorgastricmucosachanges
AT costinandreiionut gastriccancerhistopathologicalcorrelationsbetweentumorandnontumorgastricmucosachanges
AT constantinvladdenis gastriccancerhistopathologicalcorrelationsbetweentumorandnontumorgastricmucosachanges
AT lomacaion gastriccancerhistopathologicalcorrelationsbetweentumorandnontumorgastricmucosachanges
AT ianosinicolaegabriel gastriccancerhistopathologicalcorrelationsbetweentumorandnontumorgastricmucosachanges
AT soceabogdan gastriccancerhistopathologicalcorrelationsbetweentumorandnontumorgastricmucosachanges
AT tutunarucristinavioleta gastriccancerhistopathologicalcorrelationsbetweentumorandnontumorgastricmucosachanges
AT zlatianovidiumircea gastriccancerhistopathologicalcorrelationsbetweentumorandnontumorgastricmucosachanges
AT ianosisimonalaura gastriccancerhistopathologicalcorrelationsbetweentumorandnontumorgastricmucosachanges
AT neagoecarmendaniela gastriccancerhistopathologicalcorrelationsbetweentumorandnontumorgastricmucosachanges
AT crafciucantoanelavalentina gastriccancerhistopathologicalcorrelationsbetweentumorandnontumorgastricmucosachanges
AT stancumariusionut gastriccancerhistopathologicalcorrelationsbetweentumorandnontumorgastricmucosachanges