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Mechanism Exploration of 3-Hinge Gyral Formation and Pattern Recognition
The 3-hinge gyral folding is the conjunction of gyrus crest lines from three different orientations. Previous studies have not explored the possible mechanisms of formation of such 3-hinge gyri, which are preserved across species in primate brains. We develop a biomechanical model to mimic the forma...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343593/ https://www.ncbi.nlm.nih.gov/pubmed/34377991 http://dx.doi.org/10.1093/texcom/tgab044 |
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author | Razavi, Mir Jalil Liu, Tianming Wang, Xianqiao |
author_facet | Razavi, Mir Jalil Liu, Tianming Wang, Xianqiao |
author_sort | Razavi, Mir Jalil |
collection | PubMed |
description | The 3-hinge gyral folding is the conjunction of gyrus crest lines from three different orientations. Previous studies have not explored the possible mechanisms of formation of such 3-hinge gyri, which are preserved across species in primate brains. We develop a biomechanical model to mimic the formation of 3-hinge patterns on a real brain and determine how special types of 3-hinge patterns form in certain areas of the model. Our computational and experimental imaging results show that most tertiary convolutions and exact locations of 3-hinge patterns after growth and folding are unpredictable, but they help explain the consistency of locations and patterns of certain 3-hinge patterns. Growing fibers within the white matter is posited as a determining factor to affect the location and shape of these 3-hinge patterns. Even if the growing fibers do not exert strong enough forces to guide gyrification directly, they still may seed a heterogeneous growth profile that leads to the formation of 3-hinge patterns in specific locations. A minor difference in initial morphology between two growing model brains can lead to distinct numbers and locations of 3-hinge patterns after folding. |
format | Online Article Text |
id | pubmed-8343593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-83435932021-08-09 Mechanism Exploration of 3-Hinge Gyral Formation and Pattern Recognition Razavi, Mir Jalil Liu, Tianming Wang, Xianqiao Cereb Cortex Commun Original Article The 3-hinge gyral folding is the conjunction of gyrus crest lines from three different orientations. Previous studies have not explored the possible mechanisms of formation of such 3-hinge gyri, which are preserved across species in primate brains. We develop a biomechanical model to mimic the formation of 3-hinge patterns on a real brain and determine how special types of 3-hinge patterns form in certain areas of the model. Our computational and experimental imaging results show that most tertiary convolutions and exact locations of 3-hinge patterns after growth and folding are unpredictable, but they help explain the consistency of locations and patterns of certain 3-hinge patterns. Growing fibers within the white matter is posited as a determining factor to affect the location and shape of these 3-hinge patterns. Even if the growing fibers do not exert strong enough forces to guide gyrification directly, they still may seed a heterogeneous growth profile that leads to the formation of 3-hinge patterns in specific locations. A minor difference in initial morphology between two growing model brains can lead to distinct numbers and locations of 3-hinge patterns after folding. Oxford University Press 2021-07-03 /pmc/articles/PMC8343593/ /pubmed/34377991 http://dx.doi.org/10.1093/texcom/tgab044 Text en © The Author(s) 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Razavi, Mir Jalil Liu, Tianming Wang, Xianqiao Mechanism Exploration of 3-Hinge Gyral Formation and Pattern Recognition |
title | Mechanism Exploration of 3-Hinge Gyral Formation and Pattern Recognition |
title_full | Mechanism Exploration of 3-Hinge Gyral Formation and Pattern Recognition |
title_fullStr | Mechanism Exploration of 3-Hinge Gyral Formation and Pattern Recognition |
title_full_unstemmed | Mechanism Exploration of 3-Hinge Gyral Formation and Pattern Recognition |
title_short | Mechanism Exploration of 3-Hinge Gyral Formation and Pattern Recognition |
title_sort | mechanism exploration of 3-hinge gyral formation and pattern recognition |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343593/ https://www.ncbi.nlm.nih.gov/pubmed/34377991 http://dx.doi.org/10.1093/texcom/tgab044 |
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