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Familial Contributions to the Association Between Low Birth Weight and Risk of CKD in Adult Life

INTRODUCTION: Previous studies have revealed that individuals with low birth weight (LBW) have higher risk of chronic kidney disease (CKD) and that LBW and CKD cluster in families. This study investigates how familial factors affect the association between birth-related risk markers and risk of CKD....

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Autores principales: Gjerde, Anna, Skrunes, Rannveig, Reisæter, Anna Varberg, Marti, Hans-Peter, Vikse, Bjørn Egil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343716/
https://www.ncbi.nlm.nih.gov/pubmed/34386664
http://dx.doi.org/10.1016/j.ekir.2021.05.032
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author Gjerde, Anna
Skrunes, Rannveig
Reisæter, Anna Varberg
Marti, Hans-Peter
Vikse, Bjørn Egil
author_facet Gjerde, Anna
Skrunes, Rannveig
Reisæter, Anna Varberg
Marti, Hans-Peter
Vikse, Bjørn Egil
author_sort Gjerde, Anna
collection PubMed
description INTRODUCTION: Previous studies have revealed that individuals with low birth weight (LBW) have higher risk of chronic kidney disease (CKD) and that LBW and CKD cluster in families. This study investigates how familial factors affect the association between birth-related risk markers and risk of CKD. METHODS: The Medical Birth Registry (MBR) of Norway has registered all births in Norway since 1967. Sibling data were available through the Norwegian Population Registry. The Norwegian Patient Registry has registered diagnostic codes for all admissions and outpatient visits to Norwegian hospitals since 2008. Data from these registries were linked. Risk of CKD according to whether the individual himself or at least one of his siblings had LBW was analyzed using logistic regression statistics. RESULTS: Of 1,847,565 individuals, 3336 had been diagnosed with CKD. Compared with individuals without LBW and no siblings with LBW, individuals without LBW but who had a sibling with LBW had adjusted odds ratio (aOR) of 1.33 (1.19–1.49), those with LBW but no siblings with LBW had aOR of 1.74 (1.55–1.95), and those with LBW and a sibling with LBW had aOR of 1.77 (1.54–2.04) for CKD. Similar results were found for LBW for gestational age, but preterm birth revealed weaker associations. CONCLUSION: Individuals who have a sibling with LBW have an increased risk of CKD later in life, and individuals who themselves have LBW have an even higher risk. Our findings suggest that there are familial contributions to the nephron endowment in utero hypothesis.
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spelling pubmed-83437162021-08-11 Familial Contributions to the Association Between Low Birth Weight and Risk of CKD in Adult Life Gjerde, Anna Skrunes, Rannveig Reisæter, Anna Varberg Marti, Hans-Peter Vikse, Bjørn Egil Kidney Int Rep Clinical Research INTRODUCTION: Previous studies have revealed that individuals with low birth weight (LBW) have higher risk of chronic kidney disease (CKD) and that LBW and CKD cluster in families. This study investigates how familial factors affect the association between birth-related risk markers and risk of CKD. METHODS: The Medical Birth Registry (MBR) of Norway has registered all births in Norway since 1967. Sibling data were available through the Norwegian Population Registry. The Norwegian Patient Registry has registered diagnostic codes for all admissions and outpatient visits to Norwegian hospitals since 2008. Data from these registries were linked. Risk of CKD according to whether the individual himself or at least one of his siblings had LBW was analyzed using logistic regression statistics. RESULTS: Of 1,847,565 individuals, 3336 had been diagnosed with CKD. Compared with individuals without LBW and no siblings with LBW, individuals without LBW but who had a sibling with LBW had adjusted odds ratio (aOR) of 1.33 (1.19–1.49), those with LBW but no siblings with LBW had aOR of 1.74 (1.55–1.95), and those with LBW and a sibling with LBW had aOR of 1.77 (1.54–2.04) for CKD. Similar results were found for LBW for gestational age, but preterm birth revealed weaker associations. CONCLUSION: Individuals who have a sibling with LBW have an increased risk of CKD later in life, and individuals who themselves have LBW have an even higher risk. Our findings suggest that there are familial contributions to the nephron endowment in utero hypothesis. Elsevier 2021-05-30 /pmc/articles/PMC8343716/ /pubmed/34386664 http://dx.doi.org/10.1016/j.ekir.2021.05.032 Text en © 2021 International Society of Nephrology. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Research
Gjerde, Anna
Skrunes, Rannveig
Reisæter, Anna Varberg
Marti, Hans-Peter
Vikse, Bjørn Egil
Familial Contributions to the Association Between Low Birth Weight and Risk of CKD in Adult Life
title Familial Contributions to the Association Between Low Birth Weight and Risk of CKD in Adult Life
title_full Familial Contributions to the Association Between Low Birth Weight and Risk of CKD in Adult Life
title_fullStr Familial Contributions to the Association Between Low Birth Weight and Risk of CKD in Adult Life
title_full_unstemmed Familial Contributions to the Association Between Low Birth Weight and Risk of CKD in Adult Life
title_short Familial Contributions to the Association Between Low Birth Weight and Risk of CKD in Adult Life
title_sort familial contributions to the association between low birth weight and risk of ckd in adult life
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343716/
https://www.ncbi.nlm.nih.gov/pubmed/34386664
http://dx.doi.org/10.1016/j.ekir.2021.05.032
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