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Interleukin 9 serum level and single nucleotide polymorphism in patients with asthma
BACKGROUND: Asthma is a chronic inflammatory disease of airways which accounts for a huge economic, morbidity, and mortality burden. There are different cytokines that contribute to asthma pathophysiology. Learning about these cytokines leads to attaining novel anti-inflammatory treatments for asthm...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mattioli 1885
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343737/ https://www.ncbi.nlm.nih.gov/pubmed/34212923 http://dx.doi.org/10.23750/abm.v92i3.10544 |
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author | Mahdaviani, Seyed Alireza Eskian, Mahsa Khorasanizadeh, MirHojjat Bashardoost, Bahram Tashayoie Nejad, Sabereh Jamaati, Hamidreza Rezaei, Arezou Sadr, Maryam Aryan, Zahra Rezaei, Nima |
author_facet | Mahdaviani, Seyed Alireza Eskian, Mahsa Khorasanizadeh, MirHojjat Bashardoost, Bahram Tashayoie Nejad, Sabereh Jamaati, Hamidreza Rezaei, Arezou Sadr, Maryam Aryan, Zahra Rezaei, Nima |
author_sort | Mahdaviani, Seyed Alireza |
collection | PubMed |
description | BACKGROUND: Asthma is a chronic inflammatory disease of airways which accounts for a huge economic, morbidity, and mortality burden. There are different cytokines that contribute to asthma pathophysiology. Learning about these cytokines leads to attaining novel anti-inflammatory treatments for asthma control. OBJECTIVES: The objective of this study is to investigate the association between interleukin-9 serum level and gene polymorphism with asthma susceptibility. METHODS: This was a case-control study of 70 asthmatic patients and 77 healthy control adults aged 18-60. Asthma diagnosis and severity were based on physician diagnosis, pulmonary function test (PFT) and 2016 guild line of Global Initiative for Asthma (GINA). Interleukin 9(IL -9) serum level was measured using sandwich enzyme linked immunosorbent assay. IL9 promoter single nucleotide polymorphism (SNP) (rs2069882) was also assessed using Real-Time PCR System. RESULTS: There was no significant association between IL-9 SNP polymorphism and asthma. IL-9 serum level was significantly associated with asthma susceptibility (p value= 0.016) and absolute eosinophil count (AEC) (P value=0.033) however, its correlation with atopic asthma type, asthma severity and Immunoglubin E serum level were not statistically significant. CONCLUSION: Although there was no association between IL-9 SNP and asthma, but IL-9 serum level was significantly correlated with asthma susceptibility and AEC. (www.actabiomedica.it) |
format | Online Article Text |
id | pubmed-8343737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Mattioli 1885 |
record_format | MEDLINE/PubMed |
spelling | pubmed-83437372021-08-23 Interleukin 9 serum level and single nucleotide polymorphism in patients with asthma Mahdaviani, Seyed Alireza Eskian, Mahsa Khorasanizadeh, MirHojjat Bashardoost, Bahram Tashayoie Nejad, Sabereh Jamaati, Hamidreza Rezaei, Arezou Sadr, Maryam Aryan, Zahra Rezaei, Nima Acta Biomed Original Article BACKGROUND: Asthma is a chronic inflammatory disease of airways which accounts for a huge economic, morbidity, and mortality burden. There are different cytokines that contribute to asthma pathophysiology. Learning about these cytokines leads to attaining novel anti-inflammatory treatments for asthma control. OBJECTIVES: The objective of this study is to investigate the association between interleukin-9 serum level and gene polymorphism with asthma susceptibility. METHODS: This was a case-control study of 70 asthmatic patients and 77 healthy control adults aged 18-60. Asthma diagnosis and severity were based on physician diagnosis, pulmonary function test (PFT) and 2016 guild line of Global Initiative for Asthma (GINA). Interleukin 9(IL -9) serum level was measured using sandwich enzyme linked immunosorbent assay. IL9 promoter single nucleotide polymorphism (SNP) (rs2069882) was also assessed using Real-Time PCR System. RESULTS: There was no significant association between IL-9 SNP polymorphism and asthma. IL-9 serum level was significantly associated with asthma susceptibility (p value= 0.016) and absolute eosinophil count (AEC) (P value=0.033) however, its correlation with atopic asthma type, asthma severity and Immunoglubin E serum level were not statistically significant. CONCLUSION: Although there was no association between IL-9 SNP and asthma, but IL-9 serum level was significantly correlated with asthma susceptibility and AEC. (www.actabiomedica.it) Mattioli 1885 2021 2021-07-01 /pmc/articles/PMC8343737/ /pubmed/34212923 http://dx.doi.org/10.23750/abm.v92i3.10544 Text en Copyright: © 2020 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Original Article Mahdaviani, Seyed Alireza Eskian, Mahsa Khorasanizadeh, MirHojjat Bashardoost, Bahram Tashayoie Nejad, Sabereh Jamaati, Hamidreza Rezaei, Arezou Sadr, Maryam Aryan, Zahra Rezaei, Nima Interleukin 9 serum level and single nucleotide polymorphism in patients with asthma |
title | Interleukin 9 serum level and single nucleotide polymorphism in patients with asthma |
title_full | Interleukin 9 serum level and single nucleotide polymorphism in patients with asthma |
title_fullStr | Interleukin 9 serum level and single nucleotide polymorphism in patients with asthma |
title_full_unstemmed | Interleukin 9 serum level and single nucleotide polymorphism in patients with asthma |
title_short | Interleukin 9 serum level and single nucleotide polymorphism in patients with asthma |
title_sort | interleukin 9 serum level and single nucleotide polymorphism in patients with asthma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343737/ https://www.ncbi.nlm.nih.gov/pubmed/34212923 http://dx.doi.org/10.23750/abm.v92i3.10544 |
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