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Comparative Bioinformatics Characteristic of Bladder Cancer Stage 2 from Stage 4 Expression Profile: A Network-Based Study
BACKGROUND: Bladder cancer (BC) has remained as one of the most challenging issues in medicine. The aim of this study was to investigate the differential network analysis of stages 2 and 4 of BC to better understand the molecular pathology of these states. MATERIALS AND METHODS: We chose gene expres...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Salvia Medical Sciences Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343782/ https://www.ncbi.nlm.nih.gov/pubmed/34466446 http://dx.doi.org/10.22086/gmj.v0i0.1279 |
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author | Zamanian Azodi, Mona Rezaei Tavirani, Mostafa Rostami-Nejad, Mohammad Rezaei-Tavirani, Majid |
author_facet | Zamanian Azodi, Mona Rezaei Tavirani, Mostafa Rostami-Nejad, Mohammad Rezaei-Tavirani, Majid |
author_sort | Zamanian Azodi, Mona |
collection | PubMed |
description | BACKGROUND: Bladder cancer (BC) has remained as one of the most challenging issues in medicine. The aim of this study was to investigate the differential network analysis of stages 2 and 4 of BC to better understand the molecular pathology of these states. MATERIALS AND METHODS: We chose gene expression data of GSE52519 from Gene Expression Omnibus (GEO) database analyzed by the GEO2R online tool. Cytoscape version 3.6.1 and its algorithms are the methods applied for the network construction and investigation of differentially expressed genes (DEG) in these states. RESULT: Our result revealed that the analysis DEGs provides useful information about a common molecular feature of stages 2 and 4 of BC. CONCLUSION: Consequently, the network finding revealed that more investigation about stage 2 is required to achieve an effective therapeutic protocol to block the transition from stage 2 to stage 4. |
format | Online Article Text |
id | pubmed-8343782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Salvia Medical Sciences Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-83437822021-08-30 Comparative Bioinformatics Characteristic of Bladder Cancer Stage 2 from Stage 4 Expression Profile: A Network-Based Study Zamanian Azodi, Mona Rezaei Tavirani, Mostafa Rostami-Nejad, Mohammad Rezaei-Tavirani, Majid Galen Med J Original Article BACKGROUND: Bladder cancer (BC) has remained as one of the most challenging issues in medicine. The aim of this study was to investigate the differential network analysis of stages 2 and 4 of BC to better understand the molecular pathology of these states. MATERIALS AND METHODS: We chose gene expression data of GSE52519 from Gene Expression Omnibus (GEO) database analyzed by the GEO2R online tool. Cytoscape version 3.6.1 and its algorithms are the methods applied for the network construction and investigation of differentially expressed genes (DEG) in these states. RESULT: Our result revealed that the analysis DEGs provides useful information about a common molecular feature of stages 2 and 4 of BC. CONCLUSION: Consequently, the network finding revealed that more investigation about stage 2 is required to achieve an effective therapeutic protocol to block the transition from stage 2 to stage 4. Salvia Medical Sciences Ltd 2018-12-17 /pmc/articles/PMC8343782/ /pubmed/34466446 http://dx.doi.org/10.22086/gmj.v0i0.1279 Text en Copyright© 2018, Galen Medical Journal. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) |
spellingShingle | Original Article Zamanian Azodi, Mona Rezaei Tavirani, Mostafa Rostami-Nejad, Mohammad Rezaei-Tavirani, Majid Comparative Bioinformatics Characteristic of Bladder Cancer Stage 2 from Stage 4 Expression Profile: A Network-Based Study |
title | Comparative Bioinformatics Characteristic of Bladder Cancer Stage 2 from Stage 4 Expression Profile: A Network-Based Study |
title_full | Comparative Bioinformatics Characteristic of Bladder Cancer Stage 2 from Stage 4 Expression Profile: A Network-Based Study |
title_fullStr | Comparative Bioinformatics Characteristic of Bladder Cancer Stage 2 from Stage 4 Expression Profile: A Network-Based Study |
title_full_unstemmed | Comparative Bioinformatics Characteristic of Bladder Cancer Stage 2 from Stage 4 Expression Profile: A Network-Based Study |
title_short | Comparative Bioinformatics Characteristic of Bladder Cancer Stage 2 from Stage 4 Expression Profile: A Network-Based Study |
title_sort | comparative bioinformatics characteristic of bladder cancer stage 2 from stage 4 expression profile: a network-based study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343782/ https://www.ncbi.nlm.nih.gov/pubmed/34466446 http://dx.doi.org/10.22086/gmj.v0i0.1279 |
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