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A Close Look at Echium amoenum Processing, Neuroactive Components, and Effects on Neuropsychiatric Disorders

Pharmacological researches in the area of herbal medicine have considerably increased over the last two centuries. Echium amoenum (known as Gol-e-Gavzaban in Persian) is a medicinal plant that has been widely used in Iranian folk medicine. In this review, databases including PubMed, Scopus, and Goog...

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Autores principales: Nouri, Mohammad, Farajdokht, Fereshteh, Torbati, Mohammadali, Ranjbar, Fatemeh, Hamedyazdan, Sanaz, Araj-khodaei, Mostafa, Sadigh-Eteghad, Saeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Salvia Medical Sciences Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343809/
https://www.ncbi.nlm.nih.gov/pubmed/34466529
http://dx.doi.org/10.31661/gmj.v8i0.1559
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author Nouri, Mohammad
Farajdokht, Fereshteh
Torbati, Mohammadali
Ranjbar, Fatemeh
Hamedyazdan, Sanaz
Araj-khodaei, Mostafa
Sadigh-Eteghad, Saeed
author_facet Nouri, Mohammad
Farajdokht, Fereshteh
Torbati, Mohammadali
Ranjbar, Fatemeh
Hamedyazdan, Sanaz
Araj-khodaei, Mostafa
Sadigh-Eteghad, Saeed
author_sort Nouri, Mohammad
collection PubMed
description Pharmacological researches in the area of herbal medicine have considerably increased over the last two centuries. Echium amoenum (known as Gol-e-Gavzaban in Persian) is a medicinal plant that has been widely used in Iranian folk medicine. In this review, databases including PubMed, Scopus, and Google Scholar were searched up. Data collecting was completed by January 2019 and available scientific reports regarding the processing methods, main chemical constituents, and effects of E. amoenum on different neuropsychiatric disorders are summarized. Thirteen five studies met the inclusion criteria. According to results, the important phytochemicals of the plant was phenolic compounds, fatty acids, rosmarinic acid, anthocyanidins, and flavonoids. Also, experimental and clinical studies demonstrated the effectiveness of E. amoenum in the treatment of several neuropsychiatric disorders such as anxiety, depression, ischemic stroke, seizure, Alzheimer’s disease, and pain. Many of these effects are, at least in part, due to its rosmarinic acid or polyphenolic compounds such as flavonoids and natural pigments such as anthocyanins. Also, fatty acids such as gamma-linolenic acid play critical role in neuroactive properties of this herb. Among these effects, only the antidepressant and anxiolytic properties of the plant extract have been examined both experimentally and clinically. There was some controversy over its toxicity effects. It seems that E. amoenum protects neurons via attenuation of oxidative stress and inflammation as well as blocking of apoptosis in the nervous system. However, more studies are necessary for assessing exact mechanisms of action in neuropsychiatric disorders, finding of bioactive ingredients, and processing methods of this plant.
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spelling pubmed-83438092021-08-30 A Close Look at Echium amoenum Processing, Neuroactive Components, and Effects on Neuropsychiatric Disorders Nouri, Mohammad Farajdokht, Fereshteh Torbati, Mohammadali Ranjbar, Fatemeh Hamedyazdan, Sanaz Araj-khodaei, Mostafa Sadigh-Eteghad, Saeed Galen Med J Review Article Pharmacological researches in the area of herbal medicine have considerably increased over the last two centuries. Echium amoenum (known as Gol-e-Gavzaban in Persian) is a medicinal plant that has been widely used in Iranian folk medicine. In this review, databases including PubMed, Scopus, and Google Scholar were searched up. Data collecting was completed by January 2019 and available scientific reports regarding the processing methods, main chemical constituents, and effects of E. amoenum on different neuropsychiatric disorders are summarized. Thirteen five studies met the inclusion criteria. According to results, the important phytochemicals of the plant was phenolic compounds, fatty acids, rosmarinic acid, anthocyanidins, and flavonoids. Also, experimental and clinical studies demonstrated the effectiveness of E. amoenum in the treatment of several neuropsychiatric disorders such as anxiety, depression, ischemic stroke, seizure, Alzheimer’s disease, and pain. Many of these effects are, at least in part, due to its rosmarinic acid or polyphenolic compounds such as flavonoids and natural pigments such as anthocyanins. Also, fatty acids such as gamma-linolenic acid play critical role in neuroactive properties of this herb. Among these effects, only the antidepressant and anxiolytic properties of the plant extract have been examined both experimentally and clinically. There was some controversy over its toxicity effects. It seems that E. amoenum protects neurons via attenuation of oxidative stress and inflammation as well as blocking of apoptosis in the nervous system. However, more studies are necessary for assessing exact mechanisms of action in neuropsychiatric disorders, finding of bioactive ingredients, and processing methods of this plant. Salvia Medical Sciences Ltd 2019-10-11 /pmc/articles/PMC8343809/ /pubmed/34466529 http://dx.doi.org/10.31661/gmj.v8i0.1559 Text en Copyright© 2019, Galen Medical Journal. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) )
spellingShingle Review Article
Nouri, Mohammad
Farajdokht, Fereshteh
Torbati, Mohammadali
Ranjbar, Fatemeh
Hamedyazdan, Sanaz
Araj-khodaei, Mostafa
Sadigh-Eteghad, Saeed
A Close Look at Echium amoenum Processing, Neuroactive Components, and Effects on Neuropsychiatric Disorders
title A Close Look at Echium amoenum Processing, Neuroactive Components, and Effects on Neuropsychiatric Disorders
title_full A Close Look at Echium amoenum Processing, Neuroactive Components, and Effects on Neuropsychiatric Disorders
title_fullStr A Close Look at Echium amoenum Processing, Neuroactive Components, and Effects on Neuropsychiatric Disorders
title_full_unstemmed A Close Look at Echium amoenum Processing, Neuroactive Components, and Effects on Neuropsychiatric Disorders
title_short A Close Look at Echium amoenum Processing, Neuroactive Components, and Effects on Neuropsychiatric Disorders
title_sort close look at echium amoenum processing, neuroactive components, and effects on neuropsychiatric disorders
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343809/
https://www.ncbi.nlm.nih.gov/pubmed/34466529
http://dx.doi.org/10.31661/gmj.v8i0.1559
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