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The Short-Term Effects of Pistacia Lentiscus Oil and Sesame Oil on Liver and Kidney Pathology of Rats and Human Cancer Cell Lines

BACKGROUND: Vegetable oils recently have been evaluated in many tissues. Pistacia lentiscus (mastic) of the Anacardiaceae family and Sesamum indicum (sesame) of the Pedaliaceae family are conventionally used in the management of gastrointestinal, lung, and skin illnesses. This assay attempts to dete...

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Autores principales: Ostovan, Maryam, Anbardar, Mohammad Hossein, Khazraei, Hajar, Fazljou, Seyyed Mohammad bagher, Khodabandeh, Zahra, Shamsdin, Seyedeh Azra, Araj Khodaei, Mostafa, Torbati, Mohammadali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Salvia Medical Sciences Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343819/
https://www.ncbi.nlm.nih.gov/pubmed/34466622
http://dx.doi.org/10.31661/gmj.v9i0.2001
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author Ostovan, Maryam
Anbardar, Mohammad Hossein
Khazraei, Hajar
Fazljou, Seyyed Mohammad bagher
Khodabandeh, Zahra
Shamsdin, Seyedeh Azra
Araj Khodaei, Mostafa
Torbati, Mohammadali
author_facet Ostovan, Maryam
Anbardar, Mohammad Hossein
Khazraei, Hajar
Fazljou, Seyyed Mohammad bagher
Khodabandeh, Zahra
Shamsdin, Seyedeh Azra
Araj Khodaei, Mostafa
Torbati, Mohammadali
author_sort Ostovan, Maryam
collection PubMed
description BACKGROUND: Vegetable oils recently have been evaluated in many tissues. Pistacia lentiscus (mastic) of the Anacardiaceae family and Sesamum indicum (sesame) of the Pedaliaceae family are conventionally used in the management of gastrointestinal, lung, and skin illnesses. This assay attempts to determine if the oral usage of mastic and sesame oils has any short-term toxic effects in vivo on the rat and evaluate the human anticancer effect in vitro. MATERIALS AND METHODS: Twenty-one male Sprague-Dewley rats were assigned to three groups randomly: (A) control, (B) mastic oil (400 mg/kg), and (C) sesame oil (2cc/kg). The effects of these oils were investigated by determining histopathological and stereological parameters after six days, and the anticancer effects were evaluated on SW48, HepG2 human cell lines. RESULTS: A mild chronic interstitial inflammation was seen in just one kidney of mastic oil group (B) and the other ones were normal. In the sesame oil group (C), mild chronic interstitial inflammation was seen in six kidneys. In the liver samples of both groups, there were no specific pathological findings. Different concentrations of mastic oil (0.1%-5%) reduced the cell viability of SW48, HepG2, HEK293t, and human fat cells. CONCLUSION: Mastic and sesame oils have some side-effects on the kidney and might not be safe at high doses in rats. Sesame oil did not have any toxic effect on HepG2 and HEK293t human cancer cells. Mastic oil treatment has inhibited specific SW48 cells, so this oil seems to be a good adjuvant to chemotherapy in colon treatments.
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spelling pubmed-83438192021-08-30 The Short-Term Effects of Pistacia Lentiscus Oil and Sesame Oil on Liver and Kidney Pathology of Rats and Human Cancer Cell Lines Ostovan, Maryam Anbardar, Mohammad Hossein Khazraei, Hajar Fazljou, Seyyed Mohammad bagher Khodabandeh, Zahra Shamsdin, Seyedeh Azra Araj Khodaei, Mostafa Torbati, Mohammadali Galen Med J Original Article BACKGROUND: Vegetable oils recently have been evaluated in many tissues. Pistacia lentiscus (mastic) of the Anacardiaceae family and Sesamum indicum (sesame) of the Pedaliaceae family are conventionally used in the management of gastrointestinal, lung, and skin illnesses. This assay attempts to determine if the oral usage of mastic and sesame oils has any short-term toxic effects in vivo on the rat and evaluate the human anticancer effect in vitro. MATERIALS AND METHODS: Twenty-one male Sprague-Dewley rats were assigned to three groups randomly: (A) control, (B) mastic oil (400 mg/kg), and (C) sesame oil (2cc/kg). The effects of these oils were investigated by determining histopathological and stereological parameters after six days, and the anticancer effects were evaluated on SW48, HepG2 human cell lines. RESULTS: A mild chronic interstitial inflammation was seen in just one kidney of mastic oil group (B) and the other ones were normal. In the sesame oil group (C), mild chronic interstitial inflammation was seen in six kidneys. In the liver samples of both groups, there were no specific pathological findings. Different concentrations of mastic oil (0.1%-5%) reduced the cell viability of SW48, HepG2, HEK293t, and human fat cells. CONCLUSION: Mastic and sesame oils have some side-effects on the kidney and might not be safe at high doses in rats. Sesame oil did not have any toxic effect on HepG2 and HEK293t human cancer cells. Mastic oil treatment has inhibited specific SW48 cells, so this oil seems to be a good adjuvant to chemotherapy in colon treatments. Salvia Medical Sciences Ltd 2020-12-29 /pmc/articles/PMC8343819/ /pubmed/34466622 http://dx.doi.org/10.31661/gmj.v9i0.2001 Text en Copyright© 2020, Galen Medical Journal. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) )
spellingShingle Original Article
Ostovan, Maryam
Anbardar, Mohammad Hossein
Khazraei, Hajar
Fazljou, Seyyed Mohammad bagher
Khodabandeh, Zahra
Shamsdin, Seyedeh Azra
Araj Khodaei, Mostafa
Torbati, Mohammadali
The Short-Term Effects of Pistacia Lentiscus Oil and Sesame Oil on Liver and Kidney Pathology of Rats and Human Cancer Cell Lines
title The Short-Term Effects of Pistacia Lentiscus Oil and Sesame Oil on Liver and Kidney Pathology of Rats and Human Cancer Cell Lines
title_full The Short-Term Effects of Pistacia Lentiscus Oil and Sesame Oil on Liver and Kidney Pathology of Rats and Human Cancer Cell Lines
title_fullStr The Short-Term Effects of Pistacia Lentiscus Oil and Sesame Oil on Liver and Kidney Pathology of Rats and Human Cancer Cell Lines
title_full_unstemmed The Short-Term Effects of Pistacia Lentiscus Oil and Sesame Oil on Liver and Kidney Pathology of Rats and Human Cancer Cell Lines
title_short The Short-Term Effects of Pistacia Lentiscus Oil and Sesame Oil on Liver and Kidney Pathology of Rats and Human Cancer Cell Lines
title_sort short-term effects of pistacia lentiscus oil and sesame oil on liver and kidney pathology of rats and human cancer cell lines
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343819/
https://www.ncbi.nlm.nih.gov/pubmed/34466622
http://dx.doi.org/10.31661/gmj.v9i0.2001
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