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Circulating Serum Amyloid A, hs-CRP and Vitamin D Levels in Postmenopausal Osteoporosis

BACKGROUND: Both vitamin D and inflammation were investigated as important players in the pathogenesis of postmenopausal osteoporosis. This study compared vitamin D, inflammatory the biomarkers serum levels and their association with bone mineral density (BMD) in case and control groups to evaluate...

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Autores principales: Safari, Anahid, Borhani-Haghighi, Afshin, Dianatpour, Mehdi, Heydari, Seyed Taghi, Foroughinia, Farzaneh, Ranjbar Omrani, Gholamhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Salvia Medical Sciences Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343903/
https://www.ncbi.nlm.nih.gov/pubmed/34466525
http://dx.doi.org/10.31661/gmj.v8i0.1548
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author Safari, Anahid
Borhani-Haghighi, Afshin
Dianatpour, Mehdi
Heydari, Seyed Taghi
Foroughinia, Farzaneh
Ranjbar Omrani, Gholamhossein
author_facet Safari, Anahid
Borhani-Haghighi, Afshin
Dianatpour, Mehdi
Heydari, Seyed Taghi
Foroughinia, Farzaneh
Ranjbar Omrani, Gholamhossein
author_sort Safari, Anahid
collection PubMed
description BACKGROUND: Both vitamin D and inflammation were investigated as important players in the pathogenesis of postmenopausal osteoporosis. This study compared vitamin D, inflammatory the biomarkers serum levels and their association with bone mineral density (BMD) in case and control groups to evaluate the possible immune-regulatory effect of vitamin D in this population. MATERIALS AND METHODS: Participants in post-menopausal age, were categorized to 44 osteoporotic vs. 44 healthy aged-matched women according to WHO criteria. Total BMD, T- scores, Z-scores as well as fracture risk were measured in both groups, using Hologic system Dual-energy X-ray absorptiometry (DEXA). Serum 25-OH vitamin D, high sensitive CRP (hs-CRP) and serum amyloid A (SAA) were compared between groups. The association between serum biomarkers level and BMD were also investigated. The same evaluations were performed for vitamin D deficient (<20 ng/mL) and non-deficient (≥20 ng/mL) subgroups. RESULTS: Vitamin D deficiency was higher in the osteoporotic group (32.6%) in comparison with the control group (25.6%), but the differences were not significant (P=0.47). There were no significant differences in serum levels of hs-CRP and SAA (P=0.83 and P=0.39) as well. No significant association between serum inflammatory biomarkers, vitamin D, and BMD were detected (P≥0.05). The results were the same for vitamin D deficient and non-deficient subgroups (P≥0.05). CONCLUSION: In the current study, the beneficial effects of vitamin D as a result of its immune-regulatory mechanisms was not reached. Larger scale studies might pave the way to define vitamin D benefits in postmenopausal osteoporosis.
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spelling pubmed-83439032021-08-30 Circulating Serum Amyloid A, hs-CRP and Vitamin D Levels in Postmenopausal Osteoporosis Safari, Anahid Borhani-Haghighi, Afshin Dianatpour, Mehdi Heydari, Seyed Taghi Foroughinia, Farzaneh Ranjbar Omrani, Gholamhossein Galen Med J Original Article BACKGROUND: Both vitamin D and inflammation were investigated as important players in the pathogenesis of postmenopausal osteoporosis. This study compared vitamin D, inflammatory the biomarkers serum levels and their association with bone mineral density (BMD) in case and control groups to evaluate the possible immune-regulatory effect of vitamin D in this population. MATERIALS AND METHODS: Participants in post-menopausal age, were categorized to 44 osteoporotic vs. 44 healthy aged-matched women according to WHO criteria. Total BMD, T- scores, Z-scores as well as fracture risk were measured in both groups, using Hologic system Dual-energy X-ray absorptiometry (DEXA). Serum 25-OH vitamin D, high sensitive CRP (hs-CRP) and serum amyloid A (SAA) were compared between groups. The association between serum biomarkers level and BMD were also investigated. The same evaluations were performed for vitamin D deficient (<20 ng/mL) and non-deficient (≥20 ng/mL) subgroups. RESULTS: Vitamin D deficiency was higher in the osteoporotic group (32.6%) in comparison with the control group (25.6%), but the differences were not significant (P=0.47). There were no significant differences in serum levels of hs-CRP and SAA (P=0.83 and P=0.39) as well. No significant association between serum inflammatory biomarkers, vitamin D, and BMD were detected (P≥0.05). The results were the same for vitamin D deficient and non-deficient subgroups (P≥0.05). CONCLUSION: In the current study, the beneficial effects of vitamin D as a result of its immune-regulatory mechanisms was not reached. Larger scale studies might pave the way to define vitamin D benefits in postmenopausal osteoporosis. Salvia Medical Sciences Ltd 2019-10-09 /pmc/articles/PMC8343903/ /pubmed/34466525 http://dx.doi.org/10.31661/gmj.v8i0.1548 Text en Copyright© 2019, Galen Medical Journal. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) )
spellingShingle Original Article
Safari, Anahid
Borhani-Haghighi, Afshin
Dianatpour, Mehdi
Heydari, Seyed Taghi
Foroughinia, Farzaneh
Ranjbar Omrani, Gholamhossein
Circulating Serum Amyloid A, hs-CRP and Vitamin D Levels in Postmenopausal Osteoporosis
title Circulating Serum Amyloid A, hs-CRP and Vitamin D Levels in Postmenopausal Osteoporosis
title_full Circulating Serum Amyloid A, hs-CRP and Vitamin D Levels in Postmenopausal Osteoporosis
title_fullStr Circulating Serum Amyloid A, hs-CRP and Vitamin D Levels in Postmenopausal Osteoporosis
title_full_unstemmed Circulating Serum Amyloid A, hs-CRP and Vitamin D Levels in Postmenopausal Osteoporosis
title_short Circulating Serum Amyloid A, hs-CRP and Vitamin D Levels in Postmenopausal Osteoporosis
title_sort circulating serum amyloid a, hs-crp and vitamin d levels in postmenopausal osteoporosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343903/
https://www.ncbi.nlm.nih.gov/pubmed/34466525
http://dx.doi.org/10.31661/gmj.v8i0.1548
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