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HBx represses WDR77 to enhance HBV replication by DDB1-mediated WDR77 degradation in the liver

Rationale: Hepatitis B x protein (HBx) is required to initiate and maintain the replication of hepatitis B virus (HBV). Protein arginine methyltransferases 5 (PRMT5) negatively regulates HBV transcription. WD repeat domain 77 protein (WDR77) greatly enhances the methyltransferase activity of PRMT5....

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Detalles Bibliográficos
Autores principales:	Yuan, Hongfeng, Zhao, Lina, Yuan, Ying, Yun, Haolin, Zheng, Wei, Geng, Yu, Yang, Guang, Wang, Yufei, Zhao, Man, Zhang, Xiaodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343998/ https://www.ncbi.nlm.nih.gov/pubmed/34373747 http://dx.doi.org/10.7150/thno.57531

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