Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition

As glutamine plays a central role in cancer metabolism, inhibition of glutaminolysis has become an ideal anticancer therapeutic target. However, glutaminolysis inhibition leads to activation of autophagy, which compromises its antitumor effect. Hence, we investigated the mechanism underlying glutami...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Shuting, Zhu, Liyuan, Zhu, Yiran, Meng, Yuan, Li, Jiaqiu, Song, Ping, Yousafzai, Neelum Aziz, Feng, Lifeng, Chen, Miaoqin, Wang, Yanmei, Jin, Hongchuan, Wang, Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343999/
https://www.ncbi.nlm.nih.gov/pubmed/34373753
http://dx.doi.org/10.7150/thno.60028

Ejemplares similares

Ejemplares similares