Emerging protein degradation strategies: expanding the scope to extracellular and membrane proteins

Classic small molecule inhibitors that directly target pathogenic proteins typically rely on the accessible binding sites to achieve prolonged occupancy and influence protein functions. The emerging targeted protein degradation (TPD) strategies exemplified by PROteolysis TArgeting Chimeras (PROTACs)...

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Detalles Bibliográficos
Autores principales: Lin, Jiayi, Jin, Jinmei, Shen, Yiwen, Zhang, Lijun, Gong, Gang, Bian, Huiting, Chen, Hongzhuan, Nagle, Dale G., Wu, Ye, Zhang, Weidong, Luan, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344007/
https://www.ncbi.nlm.nih.gov/pubmed/34373745
http://dx.doi.org/10.7150/thno.62686

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