Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth

Chromosome translocations involving mixed lineage leukemia (MLL) gene cause acute leukemia with a poor prognosis. MLL is frequently fused with transcription cofactors AF4 (~35%), AF9 (25%) or its paralog ENL (10%). The AHD domain of AF9/ENL binds to AF4, its paralog AFF4, or histone-H3 lysine-79 (H3...

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Detalles Bibliográficos
Autores principales: Wu, Fangrui, Nie, Shenyou, Yao, Yuan, Huo, Tong, Li, Xin, Wu, Xiaowei, Zhao, Jidong, Lin, Yi-Lun, Zhang, Yinjie, Mo, Qianxing, Song, Yongcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344022/
https://www.ncbi.nlm.nih.gov/pubmed/34373735
http://dx.doi.org/10.7150/thno.56737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344022/
https://www.ncbi.nlm.nih.gov/pubmed/34373735
http://dx.doi.org/10.7150/thno.56737

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