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Prognostic Impact of Monocyte to Lymphocyte Ratio in Clinical Outcome of Patients with Hepatocellular Carcinoma: A Systematic Review and Meta-analysis

BACKGROUND: Lymphocyte to monocyte ratio (LMR) is a surrogate marker of systemic inflammation which is shown to be related to the patient’s survival in multiple malignancies. An important implication of this marker potentially is neoplasms in which there is no correlation between prognosis and histo...

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Autores principales: Nouri-Vaskeh, Masoud, Mirza-Aghazadeh-Attari, Mohammad, Pashazadeh, Fariba, Azami-Aghdash, Saber, Alizadeh, Hadi, Pouya, Parnia, Halimi, Monireh, Jadideslam, Golamreza, Zarei, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Salvia Medical Sciences Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344106/
https://www.ncbi.nlm.nih.gov/pubmed/34466618
http://dx.doi.org/10.31661/gmj.v9i0.1948
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author Nouri-Vaskeh, Masoud
Mirza-Aghazadeh-Attari, Mohammad
Pashazadeh, Fariba
Azami-Aghdash, Saber
Alizadeh, Hadi
Pouya, Parnia
Halimi, Monireh
Jadideslam, Golamreza
Zarei, Mohammad
author_facet Nouri-Vaskeh, Masoud
Mirza-Aghazadeh-Attari, Mohammad
Pashazadeh, Fariba
Azami-Aghdash, Saber
Alizadeh, Hadi
Pouya, Parnia
Halimi, Monireh
Jadideslam, Golamreza
Zarei, Mohammad
author_sort Nouri-Vaskeh, Masoud
collection PubMed
description BACKGROUND: Lymphocyte to monocyte ratio (LMR) is a surrogate marker of systemic inflammation which is shown to be related to the patient’s survival in multiple malignancies. An important implication of this marker potentially is neoplasms in which there is no correlation between prognosis and histopathological staging and also has no reliable chemical markers associated with prognosis. Herein, this meta-analysis aimed to investigate the prognostic role of LMR in patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: In the current systemic review and meta-analysis, we conducted a systemic search of databases and indexing sources, including PubMed, EMBASE, Cochrane, Scopus, and ProQuest up to May 2019 toinclude studies on the prognostic significance of LMR on patients with HCC. Overall survival (OS), disease-free survival (DFS) and recurrence-free survival (RFS) values were extracted from the studies and analyzed. The pooled hazard ratio with a 95% confidence interval was explored to identify the prognostic value of the LMR in the survival of the patients with HCC. RESULTS: A total of 12 studies with a total sample size of 3750 cases were included. There was significant heterogeneity among the studies; therefore, subgroup analysis was also performed. Overall analysis regarding OS showed an insignificant relationship between LMR and patient’s prognosis, dividing to subgroups based on LMR cut-offs did not yield any significant result, subgroup analysis for RFS founded statistically significant results and LMR was significantly related to DFS. CONCLUSION: High LMR was associated with increased DFS and RFS, in return this association was not observed for OS.
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spelling pubmed-83441062021-08-30 Prognostic Impact of Monocyte to Lymphocyte Ratio in Clinical Outcome of Patients with Hepatocellular Carcinoma: A Systematic Review and Meta-analysis Nouri-Vaskeh, Masoud Mirza-Aghazadeh-Attari, Mohammad Pashazadeh, Fariba Azami-Aghdash, Saber Alizadeh, Hadi Pouya, Parnia Halimi, Monireh Jadideslam, Golamreza Zarei, Mohammad Galen Med J Review Article BACKGROUND: Lymphocyte to monocyte ratio (LMR) is a surrogate marker of systemic inflammation which is shown to be related to the patient’s survival in multiple malignancies. An important implication of this marker potentially is neoplasms in which there is no correlation between prognosis and histopathological staging and also has no reliable chemical markers associated with prognosis. Herein, this meta-analysis aimed to investigate the prognostic role of LMR in patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: In the current systemic review and meta-analysis, we conducted a systemic search of databases and indexing sources, including PubMed, EMBASE, Cochrane, Scopus, and ProQuest up to May 2019 toinclude studies on the prognostic significance of LMR on patients with HCC. Overall survival (OS), disease-free survival (DFS) and recurrence-free survival (RFS) values were extracted from the studies and analyzed. The pooled hazard ratio with a 95% confidence interval was explored to identify the prognostic value of the LMR in the survival of the patients with HCC. RESULTS: A total of 12 studies with a total sample size of 3750 cases were included. There was significant heterogeneity among the studies; therefore, subgroup analysis was also performed. Overall analysis regarding OS showed an insignificant relationship between LMR and patient’s prognosis, dividing to subgroups based on LMR cut-offs did not yield any significant result, subgroup analysis for RFS founded statistically significant results and LMR was significantly related to DFS. CONCLUSION: High LMR was associated with increased DFS and RFS, in return this association was not observed for OS. Salvia Medical Sciences Ltd 2020-12-25 /pmc/articles/PMC8344106/ /pubmed/34466618 http://dx.doi.org/10.31661/gmj.v9i0.1948 Text en Copyright© 2020, Galen Medical Journal. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) )
spellingShingle Review Article
Nouri-Vaskeh, Masoud
Mirza-Aghazadeh-Attari, Mohammad
Pashazadeh, Fariba
Azami-Aghdash, Saber
Alizadeh, Hadi
Pouya, Parnia
Halimi, Monireh
Jadideslam, Golamreza
Zarei, Mohammad
Prognostic Impact of Monocyte to Lymphocyte Ratio in Clinical Outcome of Patients with Hepatocellular Carcinoma: A Systematic Review and Meta-analysis
title Prognostic Impact of Monocyte to Lymphocyte Ratio in Clinical Outcome of Patients with Hepatocellular Carcinoma: A Systematic Review and Meta-analysis
title_full Prognostic Impact of Monocyte to Lymphocyte Ratio in Clinical Outcome of Patients with Hepatocellular Carcinoma: A Systematic Review and Meta-analysis
title_fullStr Prognostic Impact of Monocyte to Lymphocyte Ratio in Clinical Outcome of Patients with Hepatocellular Carcinoma: A Systematic Review and Meta-analysis
title_full_unstemmed Prognostic Impact of Monocyte to Lymphocyte Ratio in Clinical Outcome of Patients with Hepatocellular Carcinoma: A Systematic Review and Meta-analysis
title_short Prognostic Impact of Monocyte to Lymphocyte Ratio in Clinical Outcome of Patients with Hepatocellular Carcinoma: A Systematic Review and Meta-analysis
title_sort prognostic impact of monocyte to lymphocyte ratio in clinical outcome of patients with hepatocellular carcinoma: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344106/
https://www.ncbi.nlm.nih.gov/pubmed/34466618
http://dx.doi.org/10.31661/gmj.v9i0.1948
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