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Design, synthesis, docking, ADMET studies, and anticancer evaluation of new 3-methylquinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in cancer angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour propagation. Accordingly, two series of new 3-methylquinoxaline derivatives have been designed and synthesised as VEGFR-2 inhibi...

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Detalles Bibliográficos
Autores principales:	Alanazi, Mohammed M., Eissa, Ibrahim H., Alsaif, Nawaf A., Obaidullah, Ahmad J., Alanazi, Wael A., Alasmari, Abdullah F., Albassam, Hussam, Elkady, Hazem, Elwan, Alaa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344243/ https://www.ncbi.nlm.nih.gov/pubmed/34340610 http://dx.doi.org/10.1080/14756366.2021.1956488

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