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Is Africa ready for mobile colistin resistance threat?
Antimicrobial resistance is a growing public health problem and a threat to effective treatment and prevention of an array of infections caused by bacteria. Africa is already faced with many socio-economic and health crises. Many countries in Africa can seldom boast of a standardized health care fac...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344256/ https://www.ncbi.nlm.nih.gov/pubmed/34377360 http://dx.doi.org/10.1080/20008686.2021.1962781 |
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author | Anyanwu, Madubuike Umunna Jaja, Ishmael Festus Oguttu, James Wabwire Jaja, Chinwe Juliana Chah, Kennedy Foinkfu Shodeinde Shoyinka, Vincent |
author_facet | Anyanwu, Madubuike Umunna Jaja, Ishmael Festus Oguttu, James Wabwire Jaja, Chinwe Juliana Chah, Kennedy Foinkfu Shodeinde Shoyinka, Vincent |
author_sort | Anyanwu, Madubuike Umunna |
collection | PubMed |
description | Antimicrobial resistance is a growing public health problem and a threat to effective treatment and prevention of an array of infections caused by bacteria. Africa is already faced with many socio-economic and health crises. Many countries in Africa can seldom boast of a standardized health care facility comparable to those in developed countries. Yet, the non-therapeutic use of COL has been banned in developed countries. However, in Africa, except for South Africa, COL is an over-the-counter (OTC) medication sold and dispensed by non-professionals/without a veterinarian’s supervision. The ban of non-therapeutic COL in developed countries has proven to reduce the development of mobile colistin resistance (MCR) in humans and animals. The unregulated use of COL has been proven to select pathogenic and commensal bacteria resistance. A transmissible plasmid-mediated colistin determinant, mobile COL resistance (mcr) gene, which is rapidly transferred/acquired horizontally or laterally intra/inter-species/genera, has been reported. A highly promiscuous mobile genetic element like plasmids containing transposons, insertion sequences, and integrons aid the carriage/rapid transfer and acquisition of these mcr genes. Hence, we highlight the danger posed by escalating colistin (COL) resistance in the continent and the impetus to halt the indiscriminate and non-therapeutic use of COL to protect public health. |
format | Online Article Text |
id | pubmed-8344256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-83442562021-08-09 Is Africa ready for mobile colistin resistance threat? Anyanwu, Madubuike Umunna Jaja, Ishmael Festus Oguttu, James Wabwire Jaja, Chinwe Juliana Chah, Kennedy Foinkfu Shodeinde Shoyinka, Vincent Infect Ecol Epidemiol Review Article Antimicrobial resistance is a growing public health problem and a threat to effective treatment and prevention of an array of infections caused by bacteria. Africa is already faced with many socio-economic and health crises. Many countries in Africa can seldom boast of a standardized health care facility comparable to those in developed countries. Yet, the non-therapeutic use of COL has been banned in developed countries. However, in Africa, except for South Africa, COL is an over-the-counter (OTC) medication sold and dispensed by non-professionals/without a veterinarian’s supervision. The ban of non-therapeutic COL in developed countries has proven to reduce the development of mobile colistin resistance (MCR) in humans and animals. The unregulated use of COL has been proven to select pathogenic and commensal bacteria resistance. A transmissible plasmid-mediated colistin determinant, mobile COL resistance (mcr) gene, which is rapidly transferred/acquired horizontally or laterally intra/inter-species/genera, has been reported. A highly promiscuous mobile genetic element like plasmids containing transposons, insertion sequences, and integrons aid the carriage/rapid transfer and acquisition of these mcr genes. Hence, we highlight the danger posed by escalating colistin (COL) resistance in the continent and the impetus to halt the indiscriminate and non-therapeutic use of COL to protect public health. Taylor & Francis 2021-08-04 /pmc/articles/PMC8344256/ /pubmed/34377360 http://dx.doi.org/10.1080/20008686.2021.1962781 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Anyanwu, Madubuike Umunna Jaja, Ishmael Festus Oguttu, James Wabwire Jaja, Chinwe Juliana Chah, Kennedy Foinkfu Shodeinde Shoyinka, Vincent Is Africa ready for mobile colistin resistance threat? |
title | Is Africa ready for mobile colistin resistance threat? |
title_full | Is Africa ready for mobile colistin resistance threat? |
title_fullStr | Is Africa ready for mobile colistin resistance threat? |
title_full_unstemmed | Is Africa ready for mobile colistin resistance threat? |
title_short | Is Africa ready for mobile colistin resistance threat? |
title_sort | is africa ready for mobile colistin resistance threat? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344256/ https://www.ncbi.nlm.nih.gov/pubmed/34377360 http://dx.doi.org/10.1080/20008686.2021.1962781 |
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