Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease

We report a patient with connective tissue disease who developed modest severe acute respiratory syndrome coronavirus 2 receptor binding domain–specific antibody levels and a lack of neutralization capacity, despite having received 3 mRNA coronavirus disease 2019 vaccines and holding anti-B-cell the...

Descripción completa

Detalles Bibliográficos
Autores principales: Peluso, Michael J, Munter, Sadie E, Lynch, Kara L, Yun, Cassandra, Torres, Leonel, Iyer, Nikita S, Donatelli, Joanna, Ryan, Lindsay, Deitchman, Amelia N, Deeks, Steven G, Rutishauser, Rachel L, Henrich, Timothy J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344490/
https://www.ncbi.nlm.nih.gov/pubmed/34395717
http://dx.doi.org/10.1093/ofid/ofab393
Descripción
Sumario:We report a patient with connective tissue disease who developed modest severe acute respiratory syndrome coronavirus 2 receptor binding domain–specific antibody levels and a lack of neutralization capacity, despite having received 3 mRNA coronavirus disease 2019 vaccines and holding anti-B-cell therapy for >7 months before vaccination. The patient developed virus-specific T-cell responses.

Ejemplares similares