Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease

We report a patient with connective tissue disease who developed modest severe acute respiratory syndrome coronavirus 2 receptor binding domain–specific antibody levels and a lack of neutralization capacity, despite having received 3 mRNA coronavirus disease 2019 vaccines and holding anti-B-cell the...

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Autores principales: Peluso, Michael J, Munter, Sadie E, Lynch, Kara L, Yun, Cassandra, Torres, Leonel, Iyer, Nikita S, Donatelli, Joanna, Ryan, Lindsay, Deitchman, Amelia N, Deeks, Steven G, Rutishauser, Rachel L, Henrich, Timothy J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344490/
https://www.ncbi.nlm.nih.gov/pubmed/34395717
http://dx.doi.org/10.1093/ofid/ofab393
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author Peluso, Michael J
Munter, Sadie E
Lynch, Kara L
Yun, Cassandra
Torres, Leonel
Iyer, Nikita S
Donatelli, Joanna
Ryan, Lindsay
Deitchman, Amelia N
Deeks, Steven G
Rutishauser, Rachel L
Henrich, Timothy J
author_facet Peluso, Michael J
Munter, Sadie E
Lynch, Kara L
Yun, Cassandra
Torres, Leonel
Iyer, Nikita S
Donatelli, Joanna
Ryan, Lindsay
Deitchman, Amelia N
Deeks, Steven G
Rutishauser, Rachel L
Henrich, Timothy J
author_sort Peluso, Michael J
collection PubMed
description We report a patient with connective tissue disease who developed modest severe acute respiratory syndrome coronavirus 2 receptor binding domain–specific antibody levels and a lack of neutralization capacity, despite having received 3 mRNA coronavirus disease 2019 vaccines and holding anti-B-cell therapy for >7 months before vaccination. The patient developed virus-specific T-cell responses.
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spelling pubmed-83444902021-08-10 Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease Peluso, Michael J Munter, Sadie E Lynch, Kara L Yun, Cassandra Torres, Leonel Iyer, Nikita S Donatelli, Joanna Ryan, Lindsay Deitchman, Amelia N Deeks, Steven G Rutishauser, Rachel L Henrich, Timothy J Open Forum Infect Dis Brief Reports We report a patient with connective tissue disease who developed modest severe acute respiratory syndrome coronavirus 2 receptor binding domain–specific antibody levels and a lack of neutralization capacity, despite having received 3 mRNA coronavirus disease 2019 vaccines and holding anti-B-cell therapy for >7 months before vaccination. The patient developed virus-specific T-cell responses. Oxford University Press 2021-07-29 /pmc/articles/PMC8344490/ /pubmed/34395717 http://dx.doi.org/10.1093/ofid/ofab393 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Peluso, Michael J
Munter, Sadie E
Lynch, Kara L
Yun, Cassandra
Torres, Leonel
Iyer, Nikita S
Donatelli, Joanna
Ryan, Lindsay
Deitchman, Amelia N
Deeks, Steven G
Rutishauser, Rachel L
Henrich, Timothy J
Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease
title Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease
title_full Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease
title_fullStr Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease
title_full_unstemmed Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease
title_short Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease
title_sort discordant virus-specific antibody levels, antibody neutralization capacity, and t-cell responses following 3 doses of sars-cov-2 vaccination in a patient with connective tissue disease
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344490/
https://www.ncbi.nlm.nih.gov/pubmed/34395717
http://dx.doi.org/10.1093/ofid/ofab393
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